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Literature DB >> 3109918

111In-tropolonate labelled platelets; studies in normals and in patients with thrombocytopenia.

H Louwes, H Beekhuis, W T Goedemans, S P Keijser, J J Schuurman.

Abstract

Human platelets were labelled with aqueous 111In-tropolonate in comparison with 111In-oxinate. In normals the labelling efficiency with 111In-tropolonate was higher (93% +/- 2%) than with 111In-oxinate (67% +/- 8%) (P less than 0.05). In cases of severe thrombocytopenia, lower labelling efficiencies were obtained. In six normals a mean platelet life of 9 days +/- 3 days and an initial recovery of 59% +/- 15% were obtained. In twelve patients with thrombocytopenia the mean platelet life was 4 days +/- 4 days and the initial recovery was 58% +/- 20%. The absolute uptake of radioactivity in spleen and in liver in both groups are reported.

Entities: Chemical Disease Species

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Year: 1987 PMID： 3109918 DOI： 10.1007/bf00252646

Source DB: PubMed Journal: Eur J Nucl Med ISSN： 0340-6997

26 in total

1. Scintigraphic diagnosis of experimental pulmonary embolism with In-111-labeled platelets.

Authors: G McIlmoyle; H H Davis; M J Welch; J L Primeau; L A Sherman; B A Siegel
Journal: J Nucl Med Date: 1977-09 Impact factor: 10.057

2. Recommended methods for radioisotope platelet survival studies: by the panel on Diagnostic Application of Radioisotopes in Hematology, International Committee for Standardization in Hematology.

Authors:
Journal: Blood Date: 1977-12 Impact factor: 22.113

3. (51Cr)platelet kinetics in thrombocytopenia. Correlation between splenic sequestration of platelets and response to splenectomy.

Authors: C A Ries; D C Price
Journal: Ann Intern Med Date: 1974-06 Impact factor: 25.391

4. Comparison of indium-111 oxinate labelled autologous granulocytes with indium-111 oxinate and indium-111 chloride as abscess scanning agents. An experimental study in an animal model.

Authors: W T Goedemans; M R Hardeman; A J Belfer
Journal: Eur J Nucl Med Date: 1980

111In-tropolonate labelled platelets; studies in normals and in patients with thrombocytopenia.

1. Scintigraphic diagnosis of experimental pulmonary embolism with In-111-labeled platelets.

2. Recommended methods for radioisotope platelet survival studies: by the panel on Diagnostic Application of Radioisotopes in Hematology, International Committee for Standardization in Hematology.

3. (51Cr)platelet kinetics in thrombocytopenia. Correlation between splenic sequestration of platelets and response to splenectomy.

4. Comparison of indium-111 oxinate labelled autologous granulocytes with indium-111 oxinate and indium-111 chloride as abscess scanning agents. An experimental study in an animal model.

Review 5. Chronic idiopathic thrombocytopenic purpura.

6. A simple and safe technique for sterile autologous platelet labelling using "Monovette" vials.

7. Indium-111 tropolone, a new high-affinity platelet label: preparation and evaluation of labeling parameters.

8. Labeling of platelets with oxine complexes of Tc-99m and In-111. Part 1. In vitro studies and survival in the rabbit.

9. Indium-III: a new radionuclide label for studying human platelet kinetics.

10. Indium-111-labelled leucocytes for localisation of abscesses.

1. Mechanisms of thrombocytopenia induced by interferon therapy for chronic hepatitis B.