BACKGROUND: Family history is a risk factor for the development of hepatocellular carcinoma (HCC). The aim of the current study was to investigate the association between family history of HCC and long-term oncologic prognosis among patients undergoing curative liver resection for hepatitis B virus (HBV)-related HCC. METHODS: Patients who underwent curative liver resection of HBV-related HCC between 2003 and 2013 were consecutively enrolled. Family history was defined as a self-reported history of HCC in a first-degree relative. Propensity score matching (PSM) and multivariable Cox-regression analyses were performed to compare overall survival (OS) and recurrence-free survival (RFS) among patients with and without a family history. RESULTS: Among 1,112 patients, 183 (16.5%) patients had a family history of HCC. Using PSM, 179 pairs of patients with and without a family history were created that had no differences in the baseline characteristics and operative variables. On matched analysis, family history was associated with decreased OS and RFS after curative-intent resection of HBV-related HCC in the propensity matching cohort (P=0.042 and 0.006, respectively). On multivariable Cox-regression analyses, a family history of HCC was associated with decreased OS (HR: 1.574; 95% CI: 1.171-2.116; P=0.003) and RFS (HR: 1.534; 95% CI: 1.176-2.002; P=0.002) after adjusting for other prognostic risk factors. CONCLUSIONS: Family history was associated with decreased OS and RFS rates among patients undergoing curative liver resection of HBV-related HCC.
BACKGROUND: Family history is a risk factor for the development of hepatocellular carcinoma (HCC). The aim of the current study was to investigate the association between family history of HCC and long-term oncologic prognosis among patients undergoing curative liver resection for hepatitis B virus (HBV)-related HCC. METHODS: Patients who underwent curative liver resection of HBV-related HCC between 2003 and 2013 were consecutively enrolled. Family history was defined as a self-reported history of HCC in a first-degree relative. Propensity score matching (PSM) and multivariable Cox-regression analyses were performed to compare overall survival (OS) and recurrence-free survival (RFS) among patients with and without a family history. RESULTS: Among 1,112 patients, 183 (16.5%) patients had a family history of HCC. Using PSM, 179 pairs of patients with and without a family history were created that had no differences in the baseline characteristics and operative variables. On matched analysis, family history was associated with decreased OS and RFS after curative-intent resection of HBV-related HCC in the propensity matching cohort (P=0.042 and 0.006, respectively). On multivariable Cox-regression analyses, a family history of HCC was associated with decreased OS (HR: 1.574; 95% CI: 1.171-2.116; P=0.003) and RFS (HR: 1.534; 95% CI: 1.176-2.002; P=0.002) after adjusting for other prognostic risk factors. CONCLUSIONS: Family history was associated with decreased OS and RFS rates among patients undergoing curative liver resection of HBV-related HCC.
Authors: Nazario Portolani; Arianna Coniglio; Sara Ghidoni; Mara Giovanelli; Anna Benetti; Guido Alberto Massimo Tiberio; Stefano Maria Giulini Journal: Ann Surg Date: 2006-02 Impact factor: 12.969
Authors: M W Yu; H C Chang; Y F Liaw; S M Lin; S D Lee; C J Liu; P J Chen; T J Hsiao; P H Lee; C J Chen Journal: J Natl Cancer Inst Date: 2000-07-19 Impact factor: 13.506
Authors: F Donato; U Gelatti; R Chiesa; A Albertini; E Bucella; P Boffetta; A Tagger; M L Ribero; G Portera; M Fasola; G Nardi Journal: Cancer Causes Control Date: 1999-10 Impact factor: 2.506
Authors: C J Chen; K Y Liang; A S Chang; Y C Chang; S N Lu; Y F Liaw; W Y Chang; M C Sheen; T M Lin Journal: Hepatology Date: 1991-03 Impact factor: 17.425
Authors: Jennifer A Chan; Jeffrey A Meyerhardt; Donna Niedzwiecki; Donna Hollis; Leonard B Saltz; Robert J Mayer; James Thomas; Paul Schaefer; Renaud Whittom; Alexander Hantel; Richard M Goldberg; Robert S Warren; Monica Bertagnolli; Charles S Fuchs Journal: JAMA Date: 2008-06-04 Impact factor: 56.272
Authors: Jian-Min Yuan; Shelly C Lu; David Van Den Berg; Sugantha Govindarajan; Zhen-Quan Zhang; Jose M Mato; Mimi C Yu Journal: Hepatology Date: 2007-09 Impact factor: 17.425