Literature DB >> 31097986

Engineering Chemistry Innovation.

Jeffrey Y Pan1.   

Abstract

Automation of chemistry at a pharmaceutical company commonly entails bringing commercial solutions in-house, reproducing manual processes with a robot, or integrating multiple instruments to eliminate human intervention. A strategy of industrializing proven approaches, while financially justifiable, however, does not encourage innovation. On the other hand, trying to automate unproven or difficult processes may seem to be risky but can actually accelerate the adoption, modification, or rejection of novel technologies. Having chemists and engineers work together to develop automation that accelerates the development and evaluation of innovative concepts is one blueprint for delivering a competitive advantage to an organization.

Entities:  

Year:  2019        PMID: 31097986      PMCID: PMC6511955          DOI: 10.1021/acsmedchemlett.9b00096

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN: 1948-5875            Impact factor:   4.345


  23 in total

1.  Comparison of preparative HPLC/MS and preparative SFC techniques for the high-throughput purification of compound libraries.

Authors:  Philip A Searle; Keithney A Glass; Jill E Hochlowski
Journal:  J Comb Chem       Date:  2004 Mar-Apr

2.  Construction and validation of an automated flow hydrogenation instrument for application in high-throughput organic chemistry.

Authors:  Bruce Clapham; Noel S Wilson; Melissa J Michmerhuizen; David P Blanchard; David M Dingle; Thomas A Nemcek; Jeffrey Y Pan; Daryl R Sauer
Journal:  J Comb Chem       Date:  2007-12-21

3.  An automated synthesis-purification-sample-management platform for the accelerated generation of pharmaceutical candidates.

Authors:  J David Sutherland; Noah P Tu; Thomas A Nemcek; Philip A Searle; Jill E Hochlowski; Stevan W Djuric; Jeffrey Y Pan
Journal:  J Lab Autom       Date:  2013-12-18

4.  Continuous flow generation and reactions of anhydrous diazomethane using a Teflon AF-2400 tube-in-tube reactor.

Authors:  Federica Mastronardi; Bernhard Gutmann; C Oliver Kappe
Journal:  Org Lett       Date:  2013-10-15       Impact factor: 6.005

5.  Purification of drugs from biological fluids by counter-current chromatography.

Authors:  Jill E Hochlowski; Jeffrey Y Pan; Philip A Searle; Wayne R Buck; Stephen G Spanton
Journal:  J Chromatogr A       Date:  2009-06-30       Impact factor: 4.759

6.  The continuous-flow synthesis of carboxylic acids using CO2 in a tube-in-tube gas permeable membrane reactor.

Authors:  Anastasios Polyzos; Matthew O'Brien; Trine P Petersen; Ian R Baxendale; Steven V Ley
Journal:  Angew Chem Int Ed Engl       Date:  2010-12-22       Impact factor: 15.336

7.  A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century.

Authors:  Alexander G Godfrey; Thierry Masquelin; Horst Hemmerle
Journal:  Drug Discov Today       Date:  2013-03-21       Impact factor: 7.851

8.  Visible-light photoredox catalysis in flow.

Authors:  Joseph W Tucker; Yuan Zhang; Timothy F Jamison; Corey R J Stephenson
Journal:  Angew Chem Int Ed Engl       Date:  2012-03-16       Impact factor: 15.336

9.  Purification of high-throughput organic synthesis libraries by counter-current chromatography.

Authors:  Frank L Wagenaar; Jill E Hochlowski; Jeffrey Y Pan; Noah P Tu; Philip A Searle
Journal:  J Chromatogr A       Date:  2008-12-06       Impact factor: 4.759

10.  A new pilot flow reactor for high-intensity ultrasound irradiation. Application to the synthesis of biodiesel.

Authors:  Pedro Cintas; Stefano Mantegna; Emanuela Calcio Gaudino; Giancarlo Cravotto
Journal:  Ultrason Sonochem       Date:  2009-12-21       Impact factor: 7.491

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  1 in total

1.  Innovations Update.

Authors:  Stevan W Djuric
Journal:  ACS Med Chem Lett       Date:  2019-06-13       Impact factor: 4.345

  1 in total

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