Yukio Kimura1, A Shioya2,3, Y Saito2, Y Oitani4,5, Y Shigemoto1, E Morimoto1, F Suzuki1, N Ikegaya6,7, Yuiko Kimura6, K Iijima6, Y Takayama6, M Iwasaki6, M Sasaki4, N Sato8. 1. From the Department of Radiology (Yukio K., Y. Shigemoto, E.M., F.S., N.S.), National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. 2. Departments of Pathology and Laboratory Medicine (A.S., Y. Saito). 3. Department of Neurology (A.S.), Mito Kyodo General Hospital, University of Tsukuba, Tsukuba, Ibaraki, Japan. 4. Child Neurology (Y.O., M.S.). 5. Department of Pediatrics (Y.O.), Tokyo Women's Medical University Medical Center East, Tokyo, Japan. 6. Neurosurgery (N.I., Yuiko K., K.I., Y.T., M.I.), National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. 7. Department of Neurosurgery (N.I.), Yokohama City University, Yokohama, Kangawa, Japan. 8. From the Department of Radiology (Yukio K., Y. Shigemoto, E.M., F.S., N.S.), National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan snoriko@ncnp.go.jp.
Abstract
BACKGROUND AND PURPOSE: The transmantle sign is a characteristic MR imaging finding often seen in focal cortical dysplasia type IIb. The transmantle sign is typically hyperintense on T2WI and FLAIR and hypointense on T1WI. However, in some cases, it shows T1 high signal. We evaluated the imaging and pathologic findings to identify the causes of the T1 high signal in the transmantle sign. MATERIALS AND METHODS: We retrospectively reviewed the preoperative imaging data of 141 consecutive patients with histologically proved focal cortical dysplasia. We selected 25 patients with focal cortical dysplasia with the transmantle sign and divided them into groups based on the pathologic focal cortical dysplasia subtype and T1 signal of the transmantle sign. We evaluated the clinical, radiologic, and pathologic findings, including the number of balloon cells and dysmorphic neurons and the severity of gliosis or calcifications and compared them among the groups. RESULTS: Nine of the 25 patients had a T1-high-signal transmantle sign; the other 16 patients did not. All 9 patients with a T1-high-signal transmantle sign were diagnosed as type IIb (group A). Of the 16 patients with no T1-high-signal transmantle sign, 13 were diagnosed as having type IIb (group B), and the other 3 patients, as type IIa (group C). The number of balloon cells was significantly higher in group A than in the other groups, but there were no differences regarding dysmorphic neurons, the severity of gliosis, or calcifications. CONCLUSIONS: Approximately 6% (9/141) of this patient series had a T1-high-signal transmantle sign, and all were type IIb. The signal may reflect a rich density of balloon cells. This finding could support the differentiation of subtypes, especially type IIb.
BACKGROUND AND PURPOSE: The transmantle sign is a characteristic MR imaging finding often seen in focal cortical dysplasia type IIb. The transmantle sign is typically hyperintense on T2WI and FLAIR and hypointense on T1WI. However, in some cases, it shows T1 high signal. We evaluated the imaging and pathologic findings to identify the causes of the T1 high signal in the transmantle sign. MATERIALS AND METHODS: We retrospectively reviewed the preoperative imaging data of 141 consecutive patients with histologically proved focal cortical dysplasia. We selected 25 patients with focal cortical dysplasia with the transmantle sign and divided them into groups based on the pathologic focal cortical dysplasia subtype and T1 signal of the transmantle sign. We evaluated the clinical, radiologic, and pathologic findings, including the number of balloon cells and dysmorphic neurons and the severity of gliosis or calcifications and compared them among the groups. RESULTS: Nine of the 25 patients had a T1-high-signal transmantle sign; the other 16 patients did not. All 9 patients with a T1-high-signal transmantle sign were diagnosed as type IIb (group A). Of the 16 patients with no T1-high-signal transmantle sign, 13 were diagnosed as having type IIb (group B), and the other 3 patients, as type IIa (group C). The number of balloon cells was significantly higher in group A than in the other groups, but there were no differences regarding dysmorphic neurons, the severity of gliosis, or calcifications. CONCLUSIONS: Approximately 6% (9/141) of this patient series had a T1-high-signal transmantle sign, and all were type IIb. The signal may reflect a rich density of balloon cells. This finding could support the differentiation of subtypes, especially type IIb.
Authors: H Fujii; N Sato; Y Kimura; M Mizutani; M Kusama; N Sumitomo; E Chiba; Y Shigemoto; M Takao; Y Takayama; M Iwasaki; E Nakagawa; H Mori Journal: AJNR Am J Neuroradiol Date: 2022-07-14 Impact factor: 4.966