Literature DB >> 31097261

Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system.

Harshada Ketkar1, Long Yang1, Gary P Wormser2, Penghua Wang1.   

Abstract

The antihelminthic drug ivermectin has been demonstrated to have antiviral activity against the Zika virus and other arboviruses in in vitro studies. The effectiveness of ivermectin for Zika virus infection, however, has never been studied in an animal model. In this study, ivermectin was found to be ineffective for prevention of a lethal infection with the Senegal strain of Zika virus in Ifnar1 knockout mice. In view of several study limitations, evaluation of ivermectin's anti-Zika virus activity in other animal models and against other Zika virus strains would be desirable.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Ivermectin; Mouse model; Treatment; Zika virus

Year:  2019        PMID： 31097261      PMCID： PMC6697611          DOI： 10.1016/j.diagmicrobio.2019.03.012

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  18 in total

Review 1.  A systematic review of experimental evidence for antiviral effects of ivermectin and an in silico analysis of ivermectin's possible mode of action against SARS-CoV-2.

Authors:  Robert T Kinobe; Leigh Owens
Journal:  Fundam Clin Pharmacol       Date:  2021-01-28       Impact factor: 2.748

2.  Possible Role of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Recovery of Post-COVID-19 Anosmia.

Authors:  Zaki F Aref; Shamardan Ezz Eldin S Bazeed; Mohammed H Hassan; Abeer S Hassan; Ali A Ghweil; Mennatallah Ali Abdelrhman Sayed; Alaa Rashad; Haggagy Mansour; Aida A Abdelmaksoud
Journal:  Infect Drug Resist       Date:  2022-09-19       Impact factor: 4.177

Review 3.  Ivermectin: An Anthelmintic, an Insecticide, and Much More.

Authors:  Richard J Martin; Alan P Robertson; Shivani Choudhary
Journal:  Trends Parasitol       Date:  2020-11-11

Review 4.  Current Strategies of Antiviral Drug Discovery for COVID-19.

Authors:  Miao Mei; Xu Tan
Journal:  Front Mol Biosci       Date:  2021-05-13

5.  Ivermectin, a new candidate therapeutic against SARS-CoV-2/COVID-19.

Authors:  Khan Sharun; Kuldeep Dhama; Shailesh Kumar Patel; Mamta Pathak; Ruchi Tiwari; Bhoj Raj Singh; Ranjit Sah; D Katterine Bonilla-Aldana; Alfonso J Rodriguez-Morales; Hakan Leblebicioglu
Journal:  Ann Clin Microbiol Antimicrob       Date:  2020-05-30       Impact factor: 3.944

6.  The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro.

Authors:  Leon Caly; Julian D Druce; Mike G Catton; David A Jans; Kylie M Wagstaff
Journal:  Antiviral Res       Date:  2020-04-03       Impact factor: 5.970

7.  The Battle against COVID 19 Pandemic: What we Need to Know Before we "Test Fire" Ivermectin.

Authors:  Kushal Banerjee; Manab Nandy; Chanchal Kumar Dalai; Shah Newaz Ahmed
Journal:  Drug Res (Stuttg)       Date:  2020-06-19

8.  Safety of inhaled ivermectin as a repurposed direct drug for treatment of COVID-19: A preclinical tolerance study.

Authors:  Suzan M Mansour; Rehab N Shamma; Kawkab A Ahmed; Nirmeen A Sabry; Gamal Esmat; Azza A Mahmoud; Amr Maged
Journal:  Int Immunopharmacol       Date:  2021-07-23       Impact factor: 4.932

9.  Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19.

Authors:  Zaki F Aref; Shamardan Ezz Eldin S Bazeed; Mohammed H Hassan; Abeer S Hassan; Alaa Rashad; Rehab G Hassan; Aida A Abdelmaksoud
Journal:  Int J Nanomedicine       Date:  2021-06-15

10.  Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen.

Authors:  Fatemeh Heidary; Reza Gharebaghi
Journal:  J Antibiot (Tokyo)       Date:  2020-06-12       Impact factor: 2.649
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