| Literature DB >> 31096215 |
Hui Du1, Lei Gao2, Jing Luan2, Hangfan Zhang2, Taiwu Xiao2.
Abstract
Diffuse large B cell lymphoma (DLBCL), an aggressive cancer of the B cells, is the most common subtype of non-Hodgkin lymphoma (NHL) worldwide. In China, the cases of DLBCL increase yearly. C-X-C chemokine receptor 4 (CXCR4) has been implicated in the migration and trafficking of malignant B cells in several hematological malignancies, and only a few reports have been published on the role of CXCR4 in the metastasis of DLBCL. This review summarizes the relevant perspectives on the functional mechanism, prognostic significance, and therapeutic applications of the CXCL12/CXCR4 axis in DLBCL, in particular DLBCL with bone marrow involvement.Entities:
Keywords: C-X-C chemokinereceptor 4; CXCL12/CXCR4 axis; Diffuse large B cell lymphoma; Functional mechanism; Therapeutic applications
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Year: 2019 PMID： 31096215 DOI： 10.1159/000497430
Source DB: PubMed Journal: Acta Haematol ISSN： 0001-5792 Impact factor: 2.195