| Literature DB >> 31096009 |
Hawa Cisse1, Véronique Vernet-Garnier2, Maxime Hentzien1, Odile Bajolet3, Delphine Lebrun4, Morgane Bonnet5, Xavier Ohl6, Saidou Diallo6, Firouzé Bani-Sadr7.
Abstract
Although the frequency of bone and joint infections caused by Enterobacter spp. is increasing, studies regarding the optimal antibiotic therapy are scarce. The objective of this retrospective study was to assess the clinical outcomes and safety of a fluoroquinolone-cotrimoxazole combination for the treatment of bone and joint infections caused by Enterobacter cloacae. Between 2010 and 2017, 30 patients with bone and joint infections caused by E. cloacae were treated with a fluoroquinolone-cotrimoxazole combination for 8-12 weeks. There were 26 cases (87%) of infection of an internal fixation device, two cases (6.6%) of pseudarthrosis with chronic osteomyelitis, and two cases (6.6%) of infection of knee and ankle prosthetic devices. The cure rate of the fluoroquinolone-cotrimoxazole combination was 80% by intention-to-treat analysis, with a mean follow-up of 29.3 ± 19.1 months. The fluoroquinolone-cotrimoxazole combination for 8-12 weeks is effective for the treatment of bone and joint infections caused by E. cloacae.Entities:
Keywords: Bone infection; Cotrimoxazole; Enterobacter cloacae; Enterobacter spp.; Fluoroquinolone; Fluoroquinolone–cotrimoxazole combination
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Year: 2019 PMID： 31096009 DOI： 10.1016/j.ijantimicag.2019.05.010
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283