Literature DB >> 3109499

Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells.

G Milligan.   

Abstract

Rat glioma C6 BU1 cells contain a pertussis toxin substrate of 40 kDa which does not appear to be identical with Gi,Go or transducin. The GTP analogue, GTP[gamma S], inhibited the rate of pertussis toxin-catalysed ADPribosylation of this protein, while the GDP analogue GDP[beta S] stimulated this reaction. A protein of the same kDa value was ADPribosylated by cholera toxin in the absence of added guanine nucleotides. It is suggested that this 40 kDa protein can be a substrate for both cholera and pertussis toxins under appropriate conditions.

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Year:  1987        PMID： 3109499     DOI： 10.1016/0167-4889(87)90176-5

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  12 in total

1.  The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding.

Authors:  S D Gardner; G Milligan; J E Rice; M J Wakelam
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857

Review 2.  Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins.

Authors:  G Milligan
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

3.  Guanine-nucleotide-binding proteins expressed in rat white adipose tissue. Identification of both mRNAs and proteins corresponding to Gi1, Gi2 and Gi3.

Authors:  F M Mitchell; S L Griffiths; E D Saggerson; M D Houslay; J T Knowler; G Milligan
Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

4.  Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs).

Authors:  G Milligan; C G Unson; M J Wakelam
Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

5.  Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.

Authors:  F R McKenzie; E C Kelly; C G Unson; A M Spiegel; G Milligan
Journal:  Biochem J       Date:  1988-02-01       Impact factor: 3.857

6.  Differential regulation of amounts of the guanine-nucleotide-binding proteins Gi and Go in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.

Authors:  I Mullaney; A I Magee; C G Unson; G Milligan
Journal:  Biochem J       Date:  1988-12-01       Impact factor: 3.857

7.  Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells.

Authors:  A Remaury; D Larrouy; D Daviaud; B Rouot; H Paris
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857

8.  The palmitoylation status of the G-protein G(o)1 alpha regulates its activity of interaction with the plasma membrane.

Authors:  M A Grassie; J F McCallum; F Guzzi; A I Magee; G Milligan; M Parenti
Journal:  Biochem J       Date:  1994-09-15       Impact factor: 3.857

9.  Cholera toxin inhibits signal transduction by several mitogens and the in vitro growth of human small-cell lung cancer.

Authors:  J Viallet; Y Sharoni; H Frucht; R T Jensen; J D Minna; E A Sausville
Journal:  J Clin Invest       Date:  1990-12       Impact factor: 14.808

10.  Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells.

Authors:  G Milligan; F R McKenzie
Journal:  Biochem J       Date:  1988-06-01       Impact factor: 3.857
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