Dinesh Kumar Chellappan1, Neoh Jia Yee2, Bhalqish Jeet Kaur Ambar Jeet Singh2, Jithendra Panneerselvam3, Thiagarajan Madheswaran3, Jestin Chellian1, Saurabh Satija4, Meenu Mehta4, Monica Gulati4, Gaurav Gupta5, Kamal Dua6,7. 1. Department of Life Sciences, International Medical University, Kuala Lumpur, Malaysia 57000. 2. School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia 57000. 3. Department of Pharmaceutical Technology, International Medical University, Kuala Lumpur, Malaysia 57000. 4. School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara-144411, Punjab, India. 5. School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, 302017, Jaipur, India. 6. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia. 7. Priority Research Centre for Healthy Lungs, School of Biomedical Sciences & Pharmacy, The University of Newcastle, Callaghan, Australia.
Abstract
Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.
Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.
Authors: Daljeet Singh Dhanjal; Parvarish Sharma; Meenu Mehta; Murtaza M Tambuwala; Parteek Prasher; Keshav R Paudel; Gang Liu; Shakti D Shukla; Philip M Hansbro; Dinesh Kumar Chellappan; Kamal Dua; Saurabh Satija Journal: Future Med Chem Date: 2022-01-12 Impact factor: 3.808
Authors: Anam Asghar; Muhammad Naeem Aamir; Fatima Akbar Sheikh; Naveed Ahmad; Mervat A Elsherif; Syed Nasir Abbas Bukhari Journal: Molecules Date: 2022-07-11 Impact factor: 4.927