Christopher Månsson1, Richard Brahmstaedt2, Peter Nygren3, Anders Nilsson2, Jozef Urdzik2, Britt-Marie Karlson2. 1. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden christopher.mansson@surgsci.uu.se. 2. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. 3. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Abstract
BACKGROUND/AIM: Irreversible electroporation (IRE) has recently been used as an experimental ablation treatment following systemic chemotherapy in locally advanced pancreatic cancer (LAPC). The primary aim of this study was to evaluate survival of LAPC patients after IRE prior to chemotherapy. The secondary aim was to examine the complication rates. PATIENTS AND METHODS: Twenty-four patients with LAPC were included and treated with percutaneous ultrasound-guided IRE under general anesthesia. Survival data from the National Quality Registry for Pancreatic and Periampullary Cancer for LAPC during the same period were used for comparison. RESULTS: The median survival after diagnosis was 13.3 months in the IRE group compared to 9.9 months in the registry group (p=0.511). Six patients had a severe complication after IRE treatment. CONCLUSION: No obvious gain in survival was observed with IRE as the first line treatment of LAPC and IRE was associated with severe complications. This study does not support percutaneous IRE in this setting. Copyright
BACKGROUND/AIM: Irreversible electroporation (IRE) has recently been used as an experimental ablation treatment following systemic chemotherapy in locally advanced pancreatic cancer (LAPC). The primary aim of this study was to evaluate survival of LAPC patients after IRE prior to chemotherapy. The secondary aim was to examine the complication rates. PATIENTS AND METHODS: Twenty-four patients with LAPC were included and treated with percutaneous ultrasound-guided IRE under general anesthesia. Survival data from the National Quality Registry for Pancreatic and Periampullary Cancer for LAPC during the same period were used for comparison. RESULTS: The median survival after diagnosis was 13.3 months in the IRE group compared to 9.9 months in the registry group (p=0.511). Six patients had a severe complication after IRE treatment. CONCLUSION: No obvious gain in survival was observed with IRE as the first line treatment of LAPC and IRE was associated with severe complications. This study does not support percutaneous IRE in this setting. Copyright
Authors: Florentine E F Timmer; Bart Geboers; Sanne Nieuwenhuizen; Evelien A C Schouten; Madelon Dijkstra; Jan J J de Vries; M Petrousjka van den Tol; Tanja D de Gruijl; Hester J Scheffer; Martijn R Meijerink Journal: Curr Oncol Rep Date: 2021-04-17 Impact factor: 5.075
Authors: Zainab L Rai; Veronica Ranieri; Daniel H Palmer; Peter Littler; Pauleh Ghaneh; Kurinchi Gurusamy; Derek Manas; Elena Pizzo; Eftychia Eirini Psarelli; Roopinder Gilmore; Praveen Peddu; David C Bartlett; Nicola de Liguori Carino; Brian R Davidson Journal: BMJ Open Date: 2022-05-12 Impact factor: 3.006