Yongdae Yoon1, Bonghye Ku2, Keunho Lee2, Yong Jin Jung3, Seung Joon Baek4. 1. College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea. 2. PSM Inc. 15F Mega Center, SKn Techno park, Seongnam, Republic of Korea. 3. Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Republic of Korea jyj0601@snu.ac.kr baeksj@snu.ac.kr. 4. College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea jyj0601@snu.ac.kr baeksj@snu.ac.kr.
Abstract
BACKGROUND/AIM: Plasma medicine is a new field that provides great potential for the treatment of human diseases including cancer in addition to sterilizing the surface of skin and facilitating wound healing. Recently, non-thermal atmospheric plasma (or cold atmospheric plasma, CAP) was introduced, not only for denaturing cells and tissues, but also for operating under the threshold of thermal damage and for chemically inducing a specific response or modification. MATERIALS AND METHODS: Microwave-mediated CAP was used in this study. RESULTS: CAP increased high-mobility group box 1 protein (HMGB1) expression, thereby increasing HMGB-1 secretion. In addition, we observed that the calreticulin (CRT) protein was concentrated at the cellular membrane when plasma was treated, representing immunogenic cell death. CONCLUSION: Overall, plasma treatment induces apoptosis via immunogenic cell death in cancer cells, implying a potential application to human cancer therapy and for the treatment of other human diseases. Copyright
BACKGROUND/AIM: Plasma medicine is a new field that provides great potential for the treatment of human diseases including cancer in addition to sterilizing the surface of skin and facilitating wound healing. Recently, non-thermal atmospheric plasma (or cold atmospheric plasma, CAP) was introduced, not only for denaturing cells and tissues, but also for operating under the threshold of thermal damage and for chemically inducing a specific response or modification. MATERIALS AND METHODS: Microwave-mediated CAP was used in this study. RESULTS: CAP increased high-mobility group box 1 protein (HMGB1) expression, thereby increasing HMGB-1 secretion. In addition, we observed that the calreticulin (CRT) protein was concentrated at the cellular membrane when plasma was treated, representing immunogenic cell death. CONCLUSION: Overall, plasma treatment induces apoptosis via immunogenic cell death in cancer cells, implying a potential application to humancancer therapy and for the treatment of other human diseases. Copyright
Authors: Hager Mohamed; Ramona Clemen; Eric Freund; Jan-Wilm Lackmann; Kristian Wende; Jennifer Connors; Elias K Haddad; Will Dampier; Brian Wigdahl; Vandana Miller; Sander Bekeschus; Fred C Krebs Journal: PLoS One Date: 2021-03-01 Impact factor: 3.240