Ara Shwan Media1,2, Martin Persson3, Navid Tajhizi4, Ulla Møller Weinreich2,5,6. 1. a Department of Cardiothoracic and Vascular Surgery , Aarhus University Hospital , Skejby , Denmark. 2. b Department of Respiratory Diseases , Aalborg University Hospital , Aalborg , Denmark. 3. c Solljungahälsan Health Center (General Practice) , Örkelljunga , Sweden. 4. d Department of Urology , Örebro University Hospital , Örebro , Sweden. 5. e Respiratory Research Center, Aalborg University Hospital , Aalborg , Denmark. 6. f The Clinical Institute , Aalborg University , Aalborg , Denmark.
Abstract
Background: In Denmark, lung cancer is the most common cause of cancer-related death and chronic obstructive pulmonary disease (COPD) is the most common comorbidity in patients with non-small cell lung cancer (NSCLC). The aim of this study was to investigate the influence of COPD and other common comorbidities on NSCLC mortality. Methods: Patients (n = 534) diagnosed with NSCLC at Aalborg University Hospital from 2008-2010 were included retrospectively in this study. Patient records were assessed and the population was dichotomized in COPD and non-COPD subgroups. Comorbidities i.e., ischemic heart disease, hypertension, diabetes mellitus, apoplexia, former malignancy, interstitial lung disease and psychiatric comorbidity were registered and a comorbidity count were calculated. Survival was assessed with log-rank test and uni- and multivariate regression analysis were performed for COPD-status and comorbidity count adjusting for age, gender, BMI, smoking exposure, cancer stage, method of treatment and eastern cooperative cancer group (ECOG) performance status score. Results: Of 534 NSCLC patients included, 470 were divided into COPD and non-COPD subgroups, 70% with COPD (329/470) and 30% without COPD (141/470). Only 32.5% of the patients in the COPD-group had previously diagnosed COPD. Log-rank test did not show statistically significant difference in survival between the COPD and non-COPD groups (p = .215). Multivariate Cox regression analysis did not show statistically significant association between overall 5-year mortality and the presence of COPD (HR-adj = 0.808, 95% CI = 0.612; 1.068) or other comorbidities (HR-adj = 1.101, 95% CI = 0.979; 1.237) when adjusted for age, BMI, gender, smoking exposure, ECOG performance status, treatment and TNM-stage. Conclusion: Our findings do not suggest that COPD nor other common comorbidities are significantly associated with higher mortality in NSCLC patients.
Background: In Denmark, lung cancer is the most common cause of cancer-related death and chronic obstructive pulmonary disease (COPD) is the most common comorbidity in patients with non-small cell lung cancer (NSCLC). The aim of this study was to investigate the influence of COPD and other common comorbidities on NSCLCmortality. Methods:Patients (n = 534) diagnosed with NSCLC at Aalborg University Hospital from 2008-2010 were included retrospectively in this study. Patient records were assessed and the population was dichotomized in COPD and non-COPD subgroups. Comorbidities i.e., ischemic heart disease, hypertension, diabetes mellitus, apoplexia, former malignancy, interstitial lung disease and psychiatric comorbidity were registered and a comorbidity count were calculated. Survival was assessed with log-rank test and uni- and multivariate regression analysis were performed for COPD-status and comorbidity count adjusting for age, gender, BMI, smoking exposure, cancer stage, method of treatment and eastern cooperative cancer group (ECOG) performance status score. Results: Of 534 NSCLCpatients included, 470 were divided into COPD and non-COPD subgroups, 70% with COPD (329/470) and 30% without COPD (141/470). Only 32.5% of the patients in the COPD-group had previously diagnosed COPD. Log-rank test did not show statistically significant difference in survival between the COPD and non-COPD groups (p = .215). Multivariate Cox regression analysis did not show statistically significant association between overall 5-year mortality and the presence of COPD (HR-adj = 0.808, 95% CI = 0.612; 1.068) or other comorbidities (HR-adj = 1.101, 95% CI = 0.979; 1.237) when adjusted for age, BMI, gender, smoking exposure, ECOG performance status, treatment and TNM-stage. Conclusion: Our findings do not suggest that COPD nor other common comorbidities are significantly associated with higher mortality in NSCLCpatients.
Authors: Francesco Perri; Anna Crispo; Franco Ionna; Paolo Muto; Francesco Caponigro; Francesco Longo; Concetta Montagnese; Pierluigi Franco; Ettore Pavone; Corrado Aversa; Agostino Guida; Sabrina Bimonte; Alessandro Ottaiano; Massimiliano Di Marzo; Giuseppe Porciello; Alfonso Amore; Egidio Celentano; Giuseppina Della Vittoria Scarpati; Marco Cascella Journal: Exp Ther Med Date: 2021-09-16 Impact factor: 2.751
Authors: Zichen Ji; Julio Hernández-Vázquez; Irene Milagros Domínguez-Zabaleta; Ziyi Xia; José María Bellón-Cano; Virginia Gallo-González; Ismael Ali-García; Carmen Matesanz-Ruiz; Ana López-de-Andrés; Rodrigo Jiménez-García; María Jesús Buendía-García; Ángela Gómez-Sacristán; Walther Iván Girón-Matute; Luis Puente-Maestu; Javier de Miguel-Díez Journal: Int J Chron Obstruct Pulmon Dis Date: 2020-10-30