| Literature DB >> 31090994 |
Dino Berthold1, Arne G A Geissler1, Sabrina Giofré1, Bernhard Breit1.
Abstract
The rhodium-catalyzed asymmetric intramolecular hydroamination of sulfonyl amides with terminal allenes is reported. It provides selective access to 5- and 6-membered N-heterocycles, scaffolds found in a large range of different bioactive compounds. Moreover, gram scale reactions, as well as the application of suitable product transformations to natural products and key intermediates thereof are demonstrated.Entities:
Keywords: allenes; allylic products; asymmetric catalysis; heterocycles; rhodium
Year: 2019 PMID： 31090994 DOI： 10.1002/anie.201904833
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336