Rahul Damani1, Stephan Mayer2, Raj Dhar3, Renee H Martin4, Paul Nyquist5, DaiWai M Olson6, Jorge H Mejia-Mantilla7, Susanne Muehlschlegel8, Edward C Jauch9, J Mocco10, Tatsushi Mutoh11, Jose I Suarez12. 1. Department of Neurology, Baylor College of Medicine, Houston, TX, USA. 2. Department of Neurology, Henry Ford Hospital, Detroit, MI, USA. 3. Department of Neurology, Washington University School of Medicine, St Louis, MO, USA. 4. Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA. 5. Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed 3014C, Baltimore, MD, 21287, USA. 6. Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, USA. 7. Fundacion Valle del Lili, Cali, Colombia. 8. Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA. 9. Department of Emergency Medicine, Medical University of South Carolina, Charleston, SC, USA. 10. Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 11. Department of Surgical Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan. 12. Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed 3014C, Baltimore, MD, 21287, USA. jsuarez5@jhmi.edu.
Abstract
BACKGROUND: Clinical studies of subarachnoid hemorrhage (SAH) and unruptured cerebral aneurysms lack uniformity in terms of variables used for assessments and clinical examination of patients which has led to difficulty in comparing studies and performing meta-analyses. The overall goal of the National Institute of Health/National Institute of Neurological Disorders and Stroke Unruptured Intracranial Aneurysms (UIA) and subarachnoid hemorrhage (SAH) Common Data Elements (CDE) Project was to provide common definitions and terminology for future unruptured intracranial aneurysm and SAH research. METHODS: This paper summarizes the recommendations of the subcommittee on SAH Assessments and Clinical Examination. The subcommittee consisted of an international and multidisciplinary panel of experts in UIA and SAH. Consensus recommendations were developed by reviewing previously published CDEs for other neurological diseases including traumatic brain injury, epilepsy and stroke, and the SAH literature. Recommendations for CDEs were classified by priority into "core," "supplemental-highly recommended," "supplemental" and "exploratory." RESULTS: We identified 248 variables for Assessments and Clinical Examination. Only the World Federation of Neurological Societies grading scale was classified as "Core." The Glasgow Coma Scale was classified as "Supplemental-Highly Recommended." All other Assessments and Clinical Examination variables were categorized as "Supplemental." CONCLUSION: The recommended Assessments and Clinical Examination variables have been collated from a large number of potentially useful scales, history, clinical presentation, laboratory, and other tests. We hope that adherence to these recommendations will facilitate the comparison of results across studies and meta-analyses of individual patient data.
BACKGROUND: Clinical studies of subarachnoid hemorrhage (SAH) and unruptured cerebral aneurysms lack uniformity in terms of variables used for assessments and clinical examination of patients which has led to difficulty in comparing studies and performing meta-analyses. The overall goal of the National Institute of Health/National Institute of Neurological Disorders and Stroke Unruptured Intracranial Aneurysms (UIA) and subarachnoid hemorrhage (SAH) Common Data Elements (CDE) Project was to provide common definitions and terminology for future unruptured intracranial aneurysm and SAH research. METHODS: This paper summarizes the recommendations of the subcommittee on SAH Assessments and Clinical Examination. The subcommittee consisted of an international and multidisciplinary panel of experts in UIA and SAH. Consensus recommendations were developed by reviewing previously published CDEs for other neurological diseases including traumatic brain injury, epilepsy and stroke, and the SAH literature. Recommendations for CDEs were classified by priority into "core," "supplemental-highly recommended," "supplemental" and "exploratory." RESULTS: We identified 248 variables for Assessments and Clinical Examination. Only the World Federation of Neurological Societies grading scale was classified as "Core." The Glasgow Coma Scale was classified as "Supplemental-Highly Recommended." All other Assessments and Clinical Examination variables were categorized as "Supplemental." CONCLUSION: The recommended Assessments and Clinical Examination variables have been collated from a large number of potentially useful scales, history, clinical presentation, laboratory, and other tests. We hope that adherence to these recommendations will facilitate the comparison of results across studies and meta-analyses of individual patient data.
Entities:
Keywords:
Aneurysm; Assessments; Clinical examination; Clinical studies; Common data elements; Data coding; Data collection; Glasgow Coma Scale; Hemorrhagic stroke; Standardization; Subarachnoid hemorrhage; World Federation of Neurological Societies
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