Xuejing Jin1, Fatima Al Sayah1, Arto Ohinmaa1, Deborah A Marshall2,3, Jeffrey A Johnson4. 1. School of Public Health, University of Alberta, 2-040 Li Ka Shing Centre for Health Research Innovation, Edmonton, AB, T6G 2E1, Canada. 2. Department of Community Health Sciences, University of Calgary, HRIC Building Room 3C58, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada. 3. Alberta Bone and Joint Health Institute, Calgary, Canada. 4. School of Public Health, University of Alberta, 2-040 Li Ka Shing Centre for Health Research Innovation, Edmonton, AB, T6G 2E1, Canada. jeffreyj@ualberta.ca.
Abstract
PURPOSE: To examine the responsiveness of the EQ-5D-3L and EQ-5D-5L among total hip/knee replacement (THR/TKR) patients. METHODS: The EQ-5D (3L or 5L) and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) have been routinely administered to all THR/TKR patients before and at 3 months after surgery in Alberta, Canada, since 2010. Patients were included in this analysis if they completed the WOMAC and the same version of EQ-5D at baseline and 3-month follow-up. The WOMAC was used as an anchor to categorize patients into 9 subgroups according to the relative change from baseline, i.e., no change, and 4 categories each for the amount of deterioration or improvement: large (≥ 70%), moderate (50% ≤ change < 70%), small but important (20% ≤ change < 50%), and very mild (0 < change ≤ 20%). The responsiveness of the EQ-5D-3L and EQ-5D-5L for each subgroup was assessed using effect size, standardized response mean, and Guyatt's Responsiveness Index. RESULTS: A total of 1594 patients completed the EQ-5D-3L and WOMAC (60% females, mean age 66 years, N = 646 [41%] THR), and 3180 completed the EQ-5D-5L and WOMAC (60% females, mean age 66 years, N = 1352 [43.2%] THR) at baseline and 3-month follow-up. For both THR and TKR patients with "small but important" improvement, the EQ-5D-5L was consistently more responsive than the EQ-5D-3L. CONCLUSION: Our study demonstrated that the EQ-5D-5L is more responsive than the EQ-5D-3L in identifying health-related quality of life changes in THR/TKR patients. We recommend using the EQ-5D-5L in longitudinal studies in this patient population.
PURPOSE: To examine the responsiveness of the EQ-5D-3L and EQ-5D-5L among total hip/knee replacement (THR/TKR) patients. METHODS: The EQ-5D (3L or 5L) and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) have been routinely administered to all THR/TKR patients before and at 3 months after surgery in Alberta, Canada, since 2010. Patients were included in this analysis if they completed the WOMAC and the same version of EQ-5D at baseline and 3-month follow-up. The WOMAC was used as an anchor to categorize patients into 9 subgroups according to the relative change from baseline, i.e., no change, and 4 categories each for the amount of deterioration or improvement: large (≥ 70%), moderate (50% ≤ change < 70%), small but important (20% ≤ change < 50%), and very mild (0 < change ≤ 20%). The responsiveness of the EQ-5D-3L and EQ-5D-5L for each subgroup was assessed using effect size, standardized response mean, and Guyatt's Responsiveness Index. RESULTS: A total of 1594 patients completed the EQ-5D-3L and WOMAC (60% females, mean age 66 years, N = 646 [41%] THR), and 3180 completed the EQ-5D-5L and WOMAC (60% females, mean age 66 years, N = 1352 [43.2%] THR) at baseline and 3-month follow-up. For both THR and TKR patients with "small but important" improvement, the EQ-5D-5L was consistently more responsive than the EQ-5D-3L. CONCLUSION: Our study demonstrated that the EQ-5D-5L is more responsive than the EQ-5D-3L in identifying health-related quality of life changes in THR/TKR patients. We recommend using the EQ-5D-5L in longitudinal studies in this patient population.
Entities:
Keywords:
EQ-5D; Measurement properties; Responsiveness; Total hip replacement; Total knee replacement
Authors: Siddharth Sripada; Harrison Loader; Man Hei Marcus Kam; Arslan Khaliq Raja; Joshua Haggart; Thomas Fawcett; Cameron Peattie; Samuel Molyneux; Nicholas Clement Journal: Adv Orthop Date: 2022-06-24
Authors: A M Garratt; H Furunes; C Hellum; T Solberg; J I Brox; K Storheim; L G Johnsen Journal: Health Qual Life Outcomes Date: 2021-05-28 Impact factor: 3.186
Authors: Arjun Bhadhuri; Paul Kind; Paola Salari; Katharina Tabea Jungo; Benoît Boland; Stephen Byrne; Stefanie Hossmann; Olivia Dalleur; Wilma Knol; Elisavet Moutzouri; Denis O'Mahony; Kevin D Murphy; Linda Wisselink; Nicolas Rodondi; Matthias Schwenkglenks Journal: Health Qual Life Outcomes Date: 2020-09-29 Impact factor: 3.186
Authors: Sunil K Panchani; Hiren M Divecha; Rebecca Lafferty; George Pavlou; Jez Oakley; Debbie Shaw; Amol Chitre; Henry Wynn Jones; Videsh Raut; Robert Smith; Anil Gambhir; Tim Board Journal: JB JS Open Access Date: 2021-07-28