| Literature DB >> 3108983 |
G Semenzato, A Cipriani, L Trentin, R Zambello, M Masciarelli, F Vinante, M Chilosi, G Pizzolo.
Abstract
We provide evidence that high levels of soluble interleukin-2 receptor (sIL-2R) are present in the serum of patients with sarcoidosis. Because sIL-2R is capable of binding to its ligand (IL-2), the increased serum levels of this molecule could induce a starvation of IL-2. This mechanism could help to explain a number of immunological abnormalities extensively reported in these patients and generally attributed to not yet identified serum inhibitory factors.Entities:
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Year: 1987 PMID： 3108983
Source DB: PubMed Journal: Sarcoidosis ISSN： 0393-1447