Vincenza Granata1, Roberta Fusco2, Sergio Venanzio Setola1, Carmine Picone1, Paolo Vallone1, Andrea Belli3, Paola Incollingo3, Vittorio Albino3, Fabiana Tatangelo4, Francesco Izzo3, Antonella Petrillo1. 1. Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale - IRCCS di Napoli, 80131, Naples, Italy. 2. Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale - IRCCS di Napoli, 80131, Naples, Italy. r.fusco@istitutotumori.na.it. 3. Hepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale - IRCCS di Napoli, 80131, Naples, Italy. 4. Pathology Diagnostic Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale - IRCCS di Napoli, 80131, Naples, Italy.
Abstract
PURPOSE: To assess major and ancillary parameters that could be correlated with Microvascular Invasion (MIV) and with histologic grade of HCC. MATERIALS AND METHODS: In this retrospective study, we assessed 62 patients (14 women-48 men; mean age, 63 years; range 38-80 years) that underwent hepatic resection for HCC. All patients were subject to Multidetector computed tomography (MDCT); 40 to Magnetic Resonance (MR) study. The radiologist assessed major and ancillary features according to LIRADS (v. 2018) and reported any radiological accessory findings if detected. RESULTS: No major feature showed statistically significant differences and correlation with grading. Mean ADC value was correlated with grading and with MIV status. No major feature was correlated to MIV; progressive contrast enhancement and satellite nodules showed statistically different percentages with respect to the presence of MIV, so as at the monovariate correlation analysis, satellite nodules were correlated with the presence of MIV. At multivariate regression analysis, no factor proved to be strong predictors of grading while progressive contrast enhancement and satellite nodules were significantly associated with the MIV. CONCLUSION: Mean ADC value is correlated to HCC grading and MIV status. Progressive contrast enhancement and the presence of satellite nodules are correlated to MIV status.
PURPOSE: To assess major and ancillary parameters that could be correlated with Microvascular Invasion (MIV) and with histologic grade of HCC. MATERIALS AND METHODS: In this retrospective study, we assessed 62 patients (14 women-48 men; mean age, 63 years; range 38-80 years) that underwent hepatic resection for HCC. All patients were subject to Multidetector computed tomography (MDCT); 40 to Magnetic Resonance (MR) study. The radiologist assessed major and ancillary features according to LIRADS (v. 2018) and reported any radiological accessory findings if detected. RESULTS: No major feature showed statistically significant differences and correlation with grading. Mean ADC value was correlated with grading and with MIV status. No major feature was correlated to MIV; progressive contrast enhancement and satellite nodules showed statistically different percentages with respect to the presence of MIV, so as at the monovariate correlation analysis, satellite nodules were correlated with the presence of MIV. At multivariate regression analysis, no factor proved to be strong predictors of grading while progressive contrast enhancement and satellite nodules were significantly associated with the MIV. CONCLUSION: Mean ADC value is correlated to HCC grading and MIV status. Progressive contrast enhancement and the presence of satellite nodules are correlated to MIV status.
Authors: Seung Baek Hong; Sang Hyun Choi; So Yeon Kim; Ju Hyun Shim; Seung Soo Lee; Jae Ho Byun; Seong Ho Park; Kyung Won Kim; Suk Kim; Nam Kyung Lee Journal: Liver Cancer Date: 2021-03-11 Impact factor: 11.740
Authors: Vincenza Granata; Roberta Grassi; Roberta Fusco; Andrea Belli; Carmen Cutolo; Silvia Pradella; Giulia Grazzini; Michelearcangelo La Porta; Maria Chiara Brunese; Federica De Muzio; Alessandro Ottaiano; Antonio Avallone; Francesco Izzo; Antonella Petrillo Journal: Infect Agent Cancer Date: 2021-07-19 Impact factor: 2.965