C Bernaud1, S Sécher2, C Michau3, P Perre4, P Fialaire5, R Vatan6, F Raffi7, C Allavena7, H Hitoto8. 1. Hôtel-Dieu university hospital, infectious and tropical disease department, 44000 Nantes, France. Electronic address: camille.bernaud@chu-nantes.fr. 2. Hôtel-Dieu university hospital, infectious and tropical disease department, 44000 Nantes, France; COREVIH Pays de la Loire, Nantes university hospital, 44000 Nantes, France. 3. Saint-Nazaire hospital, internal medicine department, Saint-Nazaire, 44600 Saint-Nazaire, France. 4. Departmental hospital, post-emergency department medicine unit, 85000 La Roche-sur-Yon, France. 5. Angers hospital, infectious and tropical disease department, 49000 Angers, France. 6. Laval hospital, internal medicine department, 53000 Laval, France. 7. Hôtel-Dieu university hospital, infectious and tropical disease department, 44000 Nantes, France. 8. Le Mans hospital, infectious and tropical disease department, 72000 Le Mans, France.
Abstract
BACKGROUND: Little data is available on HIV-infected patients aged over 75years. METHODS: A descriptive study of HIV-infected patients aged over 75years was conducted in six hospitals of the Pays de la Loire region, France. Socio-demographic, immuno-virological, and therapeutic characteristics were collected via an electronic medical record software (Nadis®). To assess frailty, a simplified geriatric assessment was conducted during an HIV routine visit. RESULTS: Among the 3965 patients followed in the six centers, 65 (1.6%) were aged over 75years. From January to May 2016, 51 patients were included in the study: median age 78.7years, male patients 74.5%, homosexual transmission 41.2%, living at home 98% and single in 54.5% of cases, median duration of HIV infection 18.8years, median CD4 nadir 181 cells/mm3; CDC stage C 36.4%. All patients were on antiretroviral therapy and 98% of them had an HIV RNA<50c/mL; 82% of patients had at least one comorbidity and 58% at least two comorbidities. Eleven of 51 patients (21.6%) were diagnosed as at risk of frailty and 2/51 (3.9%) were considered frail. Cognitive disorders were diagnosed in 60.8%, depression in 35.3%, malnutrition in 25.5%, and vitamin D deficiency in 45.9%. CONCLUSIONS: HIV-infected patients aged above 75years are well-managed, but the prevalence of geriatric comorbidities is high.
BACKGROUND: Little data is available on HIV-infectedpatients aged over 75years. METHODS: A descriptive study of HIV-infectedpatients aged over 75years was conducted in six hospitals of the Pays de la Loire region, France. Socio-demographic, immuno-virological, and therapeutic characteristics were collected via an electronic medical record software (Nadis®). To assess frailty, a simplified geriatric assessment was conducted during an HIV routine visit. RESULTS: Among the 3965 patients followed in the six centers, 65 (1.6%) were aged over 75years. From January to May 2016, 51 patients were included in the study: median age 78.7years, male patients 74.5%, homosexual transmission 41.2%, living at home 98% and single in 54.5% of cases, median duration of HIV infection 18.8years, median CD4 nadir 181 cells/mm3; CDC stage C 36.4%. All patients were on antiretroviral therapy and 98% of them had an HIV RNA<50c/mL; 82% of patients had at least one comorbidity and 58% at least two comorbidities. Eleven of 51 patients (21.6%) were diagnosed as at risk of frailty and 2/51 (3.9%) were considered frail. Cognitive disorders were diagnosed in 60.8%, depression in 35.3%, malnutrition in 25.5%, and vitamin D deficiency in 45.9%. CONCLUSIONS:HIV-infectedpatients aged above 75years are well-managed, but the prevalence of geriatric comorbidities is high.