Karen J Gibbins1, Halit Pinar2, Uma M Reddy3, George R Saade4, Robert L Goldenberg5, Donald J Dudley6, Carolyn Drews-Botsch7, Alexa Ann Freedman7, Lauren M Daniels7, Corette B Parker8, Vanessa Thorsten8, Radek Bukowski9, Robert M Silver10. 1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon. 2. Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island. 3. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Yale School of Medicine, New Haven, Connecticut. 4. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas. 5. Department of Obstetrics and Gynecology, Columbia University School of Medicine, New York. 6. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, Virginia. 7. Department of Epidemiology, Emory University, Atlanta, Georgia. 8. RTI International, Durham, North Carolina. 9. Department of Women's Health, University of Texas at Austin, Austin, Texas. 10. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, Utah.
Abstract
OBJECTIVE: Placental disease is a leading cause of stillbirth. Our purpose was to characterize stillbirths associated with placental disease. STUDY DESIGN: The Stillbirth Collaborative Research Network conducted a prospective, case-control study of stillbirths and live births from 2006 to 2008. This analysis includes 512 stillbirths with cause of death assignment and a comparison group of live births. We compared exposures between women with stillbirth due to placental disease and those due to other causes as well as between women with term (≥ 37 weeks) stillbirth due to placental disease and term live births. RESULTS: A total of 121 (23.6%) out of 512 stillbirths had a probable or possible cause of death due to placental disease by Initial Causes of Fetal Death. Characteristics were similar between stillbirths due to placental disease and other stillbirths. When comparing term live births to stillbirths due to placental disease, women with non-Hispanic black race, Hispanic ethnicity, lack of insurance, or who were born outside of the United States had higher odds of stillbirth due to placental disease. Nulliparity and antenatal bleeding also increased risk of stillbirth due to placental disease. CONCLUSION: Multiple discrete exposures were associated with stillbirth caused by placental disease. The relationship between these factors and utility of surveillance warrants further study. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE:Placental disease is a leading cause of stillbirth. Our purpose was to characterize stillbirths associated with placental disease. STUDY DESIGN: The Stillbirth Collaborative Research Network conducted a prospective, case-control study of stillbirths and live births from 2006 to 2008. This analysis includes 512 stillbirths with cause of death assignment and a comparison group of live births. We compared exposures between women with stillbirth due to placental disease and those due to other causes as well as between women with term (≥ 37 weeks) stillbirth due to placental disease and term live births. RESULTS: A total of 121 (23.6%) out of 512 stillbirths had a probable or possible cause of death due to placental disease by Initial Causes of Fetal Death. Characteristics were similar between stillbirths due to placental disease and other stillbirths. When comparing term live births to stillbirths due to placental disease, women with non-Hispanic black race, Hispanic ethnicity, lack of insurance, or who were born outside of the United States had higher odds of stillbirth due to placental disease. Nulliparity and antenatal bleeding also increased risk of stillbirth due to placental disease. CONCLUSION: Multiple discrete exposures were associated with stillbirth caused by placental disease. The relationship between these factors and utility of surveillance warrants further study. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: Matthias C Schabel; Victoria H J Roberts; Karen J Gibbins; Monica Rincon; Jessica E Gaffney; Aaron D Streblow; Adam M Wright; Jamie O Lo; Byung Park; Christopher D Kroenke; Kathryn Szczotka; Nathan R Blue; Jessica M Page; Kathy Harvey; Michael W Varner; Robert M Silver; Antonio E Frias Journal: PLoS One Date: 2022-07-19 Impact factor: 3.752
Authors: Jill K Tjon; Phillis Lakeman; Elisabeth van Leeuwen; Quinten Waisfisz; Marjan M Weiss; Gita M B Tan-Sindhunata; Peter G J Nikkels; Patrick J P van der Voorn; Gajja S Salomons; George L Burchell; Ingeborg H Linskens; Bloeme J van der Knoop; Johanna I P de Vries Journal: Mol Genet Genomic Med Date: 2021-10-12 Impact factor: 2.183