Sean He1,2,3, Alyssa T Brooks4, Kyle M Kampman1,5, Subhajit Chakravorty1,5. 1. Department of R & D, Cpl. Michael J. Crescenz VA Medical Center, PA, USA. 2. School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA. 3. St. Louis University School of Medicine, St. Louis, MO, USA. 4. Department of Nursing, National Institutes of Health Clinical Center, Bethesda, MD, USA. 5. Department of Psychiatry, Perelman School of Medicine, Philadelphia, PA, USA.
Abstract
AIM: This preliminary investigation evaluated the link between alcohol craving and insomnia in actively drinking patients with alcohol dependence (AD). METHODS: We conducted a secondary analysis of data from a clinical trial of treatment-seeking patients with AD who drank heavily (N = 61). The Penn Alcohol Craving Scale (PACS) evaluated alcohol craving, and the Short Sleep Index (SSI) assessed insomnia symptoms. We used linear regression models for baseline cross-sectional assessments. Linear mixed effects regression models evaluated craving scores longitudinally across insomnia groups (+/-), and insomnia scores longitudinally across craving groups(high/low). These longitudinal analyses were conducted separately in those treated with placebo (N = 32) and quetiapine (N = 29). RESULTS: The mean (standard deviation) for PACS total score was 15.9 (8.5) and for SSI was 2.1 (2.3). Alcohol craving was associated with the insomnia symptom of difficulty falling asleep (P = 0.03; effect size = -0.7) and with the SSI total score (P = 0.04, effect size = -0.7). In the longitudinal analysis, insomnia+ subjects had consistently higher PACS total scores, relative to the insomnia- group. The PACS score demonstrated significant group × time interactions in both treatment groups. Insomnia+ individuals demonstrated a relatively steeper rate of decline in the craving with quetiapine treatment (P = 0.03). Insomnia- individuals in the placebo group demonstrated a transient reduction in craving until week 8, followed by an increase in scores(P = 0.004). The SSI score did not demonstrate any interactive effect over time across the craving groups in either treatment arm. CONCLUSION:Insomnia was associated with higher alcohol craving and quetiapine differentially reduced craving in those with insomnia. Medical Council on Alcohol and Oxford University Press 2019. This work is written by (a) US Government employee(s) and is in the public domain in the US.
RCT Entities:
AIM: This preliminary investigation evaluated the link between alcohol craving and insomnia in actively drinking patients with alcohol dependence (AD). METHODS: We conducted a secondary analysis of data from a clinical trial of treatment-seeking patients with AD who drank heavily (N = 61). The Penn Alcohol Craving Scale (PACS) evaluated alcohol craving, and the Short Sleep Index (SSI) assessed insomnia symptoms. We used linear regression models for baseline cross-sectional assessments. Linear mixed effects regression models evaluated craving scores longitudinally across insomnia groups (+/-), and insomnia scores longitudinally across craving groups(high/low). These longitudinal analyses were conducted separately in those treated with placebo (N = 32) and quetiapine (N = 29). RESULTS: The mean (standard deviation) for PACS total score was 15.9 (8.5) and for SSI was 2.1 (2.3). Alcohol craving was associated with the insomnia symptom of difficulty falling asleep (P = 0.03; effect size = -0.7) and with the SSI total score (P = 0.04, effect size = -0.7). In the longitudinal analysis, insomnia+ subjects had consistently higher PACS total scores, relative to the insomnia- group. The PACS score demonstrated significant group × time interactions in both treatment groups. Insomnia+ individuals demonstrated a relatively steeper rate of decline in the craving with quetiapine treatment (P = 0.03). Insomnia- individuals in the placebo group demonstrated a transient reduction in craving until week 8, followed by an increase in scores(P = 0.004). The SSI score did not demonstrate any interactive effect over time across the craving groups in either treatment arm. CONCLUSION:Insomnia was associated with higher alcohol craving and quetiapine differentially reduced craving in those with insomnia. Medical Council on Alcohol and Oxford University Press 2019. This work is written by (a) US Government employee(s) and is in the public domain in the US.
Authors: Barbara A Flannery; John P Allen; Helen M Pettinati; Damaris J Rohsenow; Ron A Cisler; Raye Z Litten Journal: Alcohol Clin Exp Res Date: 2002-03 Impact factor: 3.455