Literature DB >> 31084514

Shedding light on RNaseH: a promising target for hepatitis B virus (HBV).

Tiffany C Edwards1, Nathan L Ponzar1, John E Tavis1.   

Abstract

Entities:  

Keywords:  Cation chelation; combination therapy; drug target; hepatitis B virus; ribonuclease H

Mesh：

Substances：

Year:  2019        PMID： 31084514      PMCID： PMC6571036          DOI： 10.1080/14728222.2019.1619697

Source DB:  PubMed          Journal:  Expert Opin Ther Targets        ISSN： 1472-8222            Impact factor:   6.902


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  16 in total

Review 1.  Antiviral therapies and prospects for a cure of chronic hepatitis B.

Authors:  Fabien Zoulim; David Durantel
Journal:  Cold Spring Harb Perspect Med       Date:  2015-04-01       Impact factor: 6.915

2.  Purification and enzymatic characterization of the hepatitis B virus ribonuclease H, a new target for antiviral inhibitors.

Authors:  Juan Antonio Villa; Daniel P Pike; Kunjan B Patel; Elena Lomonosova; Gaofeng Lu; Roz Abdulqader; John E Tavis
Journal:  Antiviral Res       Date:  2016-06-17       Impact factor: 5.970

3.  Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.

Authors:  Gaofeng Lu; Elena Lomonosova; Xiaohong Cheng; Eileen A Moran; Marvin J Meyers; Stuart F J Le Grice; Craig J Thomas; Jian-kang Jiang; Christine Meck; Danielle R Hirsch; Michael P D'Erasmo; Duygu M Suyabatmaz; Ryan P Murelli; John E Tavis
Journal:  Antimicrob Agents Chemother       Date:  2014-12-01       Impact factor: 5.191

Review 4.  The hepatitis B virus ribonuclease H as a drug target.

Authors:  John E Tavis; Elena Lomonosova
Journal:  Antiviral Res       Date:  2015-04-08       Impact factor: 5.970

5.  3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H.

Authors:  Andrew D Huber; Eleftherios Michailidis; Jing Tang; Maritza N Puray-Chavez; Maria Boftsi; Jennifer J Wolf; Kelsey N Boschert; Megan A Sheridan; Maxwell D Leslie; Karen A Kirby; Kamalendra Singh; Hiroaki Mitsuya; Michael A Parniak; Zhengqiang Wang; Stefan G Sarafianos
Journal:  Antimicrob Agents Chemother       Date:  2017-05-24       Impact factor: 5.191

6.  Hepatitis B virus genetic diversity has minimal impact on sensitivity of the viral ribonuclease H to inhibitors.

Authors:  Gaofeng Lu; Juan Antonio Villa; Maureen J Donlin; Tiffany C Edwards; Xiaohong Cheng; Richard F Heier; Marvin J Meyers; John E Tavis
Journal:  Antiviral Res       Date:  2016-09-28       Impact factor: 5.970

7.  Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.

Authors:  Daniel M Himmel; Karen A Maegley; Tom A Pauly; Joseph D Bauman; Kalyan Das; Chhaya Dharia; Arthur D Clark; Kevin Ryan; Michael J Hickey; Robert A Love; Stephen H Hughes; Simon Bergqvist; Eddy Arnold
Journal:  Structure       Date:  2009-12-09       Impact factor: 5.006

Review 8.  Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis.

Authors:  Anna S F Lok; Brian J McMahon; Robert S Brown; John B Wong; Ahmed T Ahmed; Wigdan Farah; Jehad Almasri; Fares Alahdab; Khalid Benkhadra; Mohamed A Mouchli; Siddharth Singh; Essa A Mohamed; Abd Moain Abu Dabrh; Larry J Prokop; Zhen Wang; Mohammad Hassan Murad; Khaled Mohammed
Journal:  Hepatology       Date:  2015-11-13       Impact factor: 17.425

9.  Synergistic Interactions between Hepatitis B Virus RNase H Antagonists and Other Inhibitors.

Authors:  Elena Lomonosova; Adam Zlotnick; John E Tavis
Journal:  Antimicrob Agents Chemother       Date:  2017-02-23       Impact factor: 5.191

10.  The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.

Authors:  John E Tavis; Xiaohong Cheng; Yuan Hu; Michael Totten; Feng Cao; Eleftherios Michailidis; Rajeev Aurora; Marvin J Meyers; E Jon Jacobsen; Michael A Parniak; Stefan G Sarafianos
Journal:  PLoS Pathog       Date:  2013-01-22       Impact factor: 6.823
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  7 in total

1.  Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection.

Authors:  Ranjit Chauhan; Qilan Li; Molly E Woodson; Makafui Gasonoo; Marvin J Meyers; John E Tavis
Journal:  Antimicrob Agents Chemother       Date:  2021-09-13       Impact factor: 5.191

2.  Alpha-hydroxytropolones are noncompetitive inhibitors of human RNase H1 that bind to the active site and modulate substrate binding.

Authors:  Nathan L Ponzar; Razia Tajwar; Nicola Pozzi; John E Tavis
Journal:  J Biol Chem       Date:  2022-03-03       Impact factor: 5.486

3.  Metal coordinating inhibitors of Rift Valley fever virus replication.

Authors:  Elizabeth Geerling; Valerie Murphy; Maria C Mai; E Taylor Stone; Andreu Gazquez Casals; Mariah Hassert; Austin T O'Dea; Feng Cao; Maureen J Donlin; Mohamed Elagawany; Bahaa Elgendy; Vasiliki Pardali; Erofili Giannakopoulou; Grigoris Zoidis; Daniel V Schiavone; Alex J Berkowitz; Nana B Agyemang; Ryan P Murelli; John E Tavis; Amelia K Pinto; James D Brien
Journal:  PLoS One       Date:  2022-09-16       Impact factor: 3.752

4.  Moving Fast Toward Hepatitis B Virus Elimination.

Authors:  Leda Bassit; Suzane Kioko Ono; Raymond F Schinazi
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 5.  Recent Advances in Hepatitis B Treatment.

Authors:  Georgia-Myrto Prifti; Dimitrios Moianos; Erofili Giannakopoulou; Vasiliki Pardali; John E Tavis; Grigoris Zoidis
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-01

6.  1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.

Authors:  Jenny Desantis; Serena Massari; Angela Corona; Andrea Astolfi; Stefano Sabatini; Giuseppe Manfroni; Deborah Palazzotti; Violetta Cecchetti; Christophe Pannecouque; Enzo Tramontano; Oriana Tabarrini
Journal:  Molecules       Date:  2020-03-05       Impact factor: 4.411

7.  3,7-Dihydroxytropolones Inhibit Initiation of Hepatitis B Virus Minus-Strand DNA Synthesis.

Authors:  Ellen Bak; Jennifer T Miller; Andrea Noronha; John Tavis; Emilio Gallicchio; Ryan P Murelli; Stuart F J Le Grice
Journal:  Molecules       Date:  2020-09-27       Impact factor: 4.411
  7 in total

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