| Literature DB >> 3108393 |
V Pancre, M Joseph, C Mazingue, J Wietzerbin, A Capron, C Auriault.
Abstract
Antigen- or mitogen-stimulated CD4+/CD- lymphocytes produced factors able to induce normal human platelets into cytotoxic effectors toward the young larvae of Schistosoma mansoni. The neutralization by monoclonal anti-IFN-gamma antibody of the induction of the platelet killer effect, the presence of IFN-gamma in the CD4+/CD8- lymphocyte supernatant, and, finally, the direct inducer effect of recombinant IFN-gamma clearly demonstrated that IFN-gamma was one of the factors responsible for the induction of platelet cytotoxic functions.Entities:
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Year: 1987 PMID： 3108393
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422