Dorothee Cäcilia Spille1, Peter B Sporns2, Katharina Heß3, Walter Stummer4, Benjamin Brokinkel4. 1. Department of Neurosurgery, University Hospital Münster, Münster, Germany. Electronic address: dorotheecaecilia.spille@ukmuenster.de. 2. Institute of Clinical Radiology, University Hospital Münster, Münster, Germany. 3. Institute of Neuropathology, University Hospital Münster, Münster, Germany. 4. Department of Neurosurgery, University Hospital Münster, Münster, Germany.
Abstract
OBJECTIVE: Estimating the risk of recurrence after surgery remains crucial during care of patients with meningioma. Numerous studies identified correlations of characteristics on routine preoperative magnetic resonance imaging (MRI) with postoperative recurrence or high-grade histology but showed partially inconclusive results. METHODS: A systematic review of the literature was performed about findings on preoperative MRI and their correlation with high-grade histology and recurrence. Quality of the included studies was analyzed using standardized Quality Assessment of Diagnostic Accuracy Studies criteria. RESULTS: Among the 35 studies included, quality of the series according to the Quality Assessment of Diagnostic Accuracy Studies criteria differed widely. Remarkably, MRI variables found to be associated with high-grade histology were commonly not consistently associated with prognosis and vice versa. Correlations of the tumor size, the peritumoral edema size, and contrast-enhancement of the tumor capsule with high-grade histology were controversial. In most studies, non-skull base tumor location, cyst formation, heterogenous contrast-enhancement, an irregular tumor shape, and disruption of the tumor/brain border but not intensity of the lesion on T2-weighted images, calcifications, or bone involvement were associated with grade II/III histology. Although tumor and edema size were usually found to correlate with recurrence, heterogenous contrast enhancement, cyst formation, intensity of the tumor on T2-weighted MRI, and enhancement of the tumor capsule were mostly not related with progression. CONCLUSIONS: Several mostly consistent but partially inconsistent variables associated with high-grade histology or prognosis were identified. Although standardized studies are needed to provide further clarification, consideration of these findings can help to improve estimation of prognosis and can therefore improve postoperative care in patients with meningioma.
OBJECTIVE: Estimating the risk of recurrence after surgery remains crucial during care of patients with meningioma. Numerous studies identified correlations of characteristics on routine preoperative magnetic resonance imaging (MRI) with postoperative recurrence or high-grade histology but showed partially inconclusive results. METHODS: A systematic review of the literature was performed about findings on preoperative MRI and their correlation with high-grade histology and recurrence. Quality of the included studies was analyzed using standardized Quality Assessment of Diagnostic Accuracy Studies criteria. RESULTS: Among the 35 studies included, quality of the series according to the Quality Assessment of Diagnostic Accuracy Studies criteria differed widely. Remarkably, MRI variables found to be associated with high-grade histology were commonly not consistently associated with prognosis and vice versa. Correlations of the tumor size, the peritumoral edema size, and contrast-enhancement of the tumor capsule with high-grade histology were controversial. In most studies, non-skull base tumor location, cyst formation, heterogenous contrast-enhancement, an irregular tumor shape, and disruption of the tumor/brain border but not intensity of the lesion on T2-weighted images, calcifications, or bone involvement were associated with grade II/III histology. Although tumor and edema size were usually found to correlate with recurrence, heterogenous contrast enhancement, cyst formation, intensity of the tumor on T2-weighted MRI, and enhancement of the tumor capsule were mostly not related with progression. CONCLUSIONS: Several mostly consistent but partially inconsistent variables associated with high-grade histology or prognosis were identified. Although standardized studies are needed to provide further clarification, consideration of these findings can help to improve estimation of prognosis and can therefore improve postoperative care in patients with meningioma.
Authors: Corey M Gill; Joshua Loewenstern; John W Rutland; Hanane Arib; Margaret Pain; Melissa Umphlett; Yayoi Kinoshita; Russell B McBride; Joshua Bederson; Michael Donovan; Robert Sebra; Mary Fowkes; Raj K Shrivastava Journal: Neuroradiology Date: 2020-08-12 Impact factor: 2.804
Authors: Lara Brunasso; Gianluca Ferini; Lapo Bonosi; Roberta Costanzo; Sofia Musso; Umberto E Benigno; Rosa M Gerardi; Giuseppe R Giammalva; Federica Paolini; Giuseppe E Umana; Francesca Graziano; Gianluca Scalia; Carmelo L Sturiale; Rina Di Bonaventura; Domenico G Iacopino; Rosario Maugeri Journal: Life (Basel) Date: 2022-04-14
Authors: Dorothee Cäcilia Spille; Alborz Adeli; Peter B Sporns; Katharina Heß; Eileen Maria Susanne Streckert; Caroline Brokinkel; Christian Mawrin; Werner Paulus; Walter Stummer; Benjamin Brokinkel Journal: Neurosurg Rev Date: 2020-04-23 Impact factor: 3.042