Literature DB >> 3108211

A transforming gene, hst, found in NIH 3T3 cells transformed with DNA from three stomach cancers and a colon cancer.

T Koda, A Sasaki, S Matsushima, M Kakinuma.   

Abstract

DNA samples from 5 out of 15 stomach cancers and from 5 out of 15 colon cancers showed transforming activity in NIH 3T3 cells upon transfection. A transforming gene from an NIH 3T3 transformant induced by transfection of DNA from a stomach cancer was cloned, and showed transforming activity amounting to 120 focus-forming units/micrograms. The transforming gene was identified as hst. The hst gene was also responsible for acquisition of the transforming activity in DNA samples from 2 other stomach cancers and one colon cancer.

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Year:  1987        PMID： 3108211

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  9 in total

1.  Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer.

Authors:  M C Yoshida; M Wada; H Satoh; T Yoshida; H Sakamoto; K Miyagawa; J Yokota; T Koda; M Kakinuma; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

2.  Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

Authors:  T Yoshida; K Miyagawa; H Odagiri; H Sakamoto; P F Little; M Terada; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

3.  The mouse homologue of hst/k-FGF: sequence, genome organization and location relative to int-2.

Authors:  S Brookes; R Smith; J Thurlow; C Dickson; G Peters
Journal:  Nucleic Acids Res       Date:  1989-06-12       Impact factor: 16.971

4.  Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue.

Authors:  W H Burgess; A M Shaheen; M Ravera; M Jaye; P J Donohue; J A Winkles
Journal:  J Cell Biol       Date:  1990-11       Impact factor: 10.539

5.  Cell transformation by kFGF requires secretion but not glycosylation.

Authors:  F Fuller-Pace; G Peters; C Dickson
Journal:  J Cell Biol       Date:  1991-10       Impact factor: 10.539

6.  Coamplification of the hst-1 and int-2 genes in human cancers.

Authors:  M Tsutsumi; H Sakamoto; T Yoshida; T Kakizoe; K Koiso; T Sugimura; M Terada
Journal:  Jpn J Cancer Res       Date:  1988-04

7.  Amplification of the hst-1 gene in human esophageal carcinomas.

Authors:  T Tsuda; H Nakatani; T Matsumura; K Yoshida; E Tahara; T Nishihira; H Sakamoto; T Yoshida; M Terada; T Sugimura
Journal:  Jpn J Cancer Res       Date:  1988-05

Review 8.  Dysregulation of growth factor-receptor system in cellular transformation.

Authors:  M Hatakeyama; T Taniguchi
Journal:  Jpn J Cancer Res       Date:  1988-08

9.  Regulation of human hst expression by an enhancer element residing in the third exon.

Authors:  A Sasaki; M Kubo; S Hasan; Y Yano; M Kakinuma
Journal:  Jpn J Cancer Res       Date:  1991-11
  9 in total

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