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Literature DB >> 3107983

Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.

A Rosenthal, L Rhee, R Yadegari, R Paro, A Ullrich, D V Goeddel.

Abstract

Genomic and cDNA clones encoding a Drosophila melanogaster protein kinase C (PKC) homologue were identified using a bovine PKC cDNA probe. The cDNA clones contain a single open reading frame that encodes a 639 amino acid, 75-kd protein having extensive homology with bovine, human and rat PKC and homology with the kinase domains of other serine, threonine and tyrosine kinases. The Drosophila PKC gene is localized to region 53E of chromosome 2. The gene spans approximately 20 kb and contains at least 14 exons. Messenger RNA for PKC could not be detected in 0-3 h Drosophila embryos. Adult flies contain three PKC transcripts of 4.3, 4.0 and 2.4 kb.

Entities: Chemical

Mesh：

Substances：
DNA
Protein Kinase C

Year: 1987 PMID： 3107983 PMCID： PMC553414 DOI： 10.1002/j.1460-2075.1987.tb04773.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

71 in total

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Authors: R H Michell
Journal: Biochim Biophys Acta Date: 1975-03-25

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Authors: P J Parker; L Coussens; N Totty; L Rhee; S Young; E Chen; S Stabel; M D Waterfield; A Ullrich
Journal: Science Date: 1986-08-22 Impact factor: 47.728

3. Ca2+-dependent and phorbol ester activating phosphorylation of a 36K-dalton protein of rat basophilic leukemia cell membranes and immunoprecipitation of the phosphorylated protein with IgE-anti IgE system.

Authors: R Teshima; H Ikebuchi; T Terao
Journal: Biochem Biophys Res Commun Date: 1984-12-28 Impact factor: 3.575

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Authors: J F Kuo; R G Andersson; B C Wise; L Mackerlova; I Salomonsson; N L Brackett; N Katoh; M Shoji; R W Wrenn
Journal: Proc Natl Acad Sci U S A Date: 1980-12 Impact factor: 11.205

5. c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF.

Authors: S R Coughlin; W M Lee; P W Williams; G M Giels; L T Williams
Journal: Cell Date: 1985-11 Impact factor: 41.582

6. Calmodulin-dependent glycogen synthase kinase.

Authors: M E Payne; T R Soderling
Journal: J Biol Chem Date: 1980-09-10 Impact factor: 5.157

7. An early decrease in phosphatidylinositol turnover occurs on induction of Friend cell differentiation and precedes the decrease in c-myc expression.

Authors: D L Faletto; A S Arrow; I G Macara
Journal: Cell Date: 1985-11 Impact factor: 41.582

8. Prostaglandin F2 alpha stimulates phosphatidylinositol turnover and increases the cellular content of 1,2-diacylglycerol in confluent resting Swiss 3T3 cells.

Authors: C H Macphee; A H Drummond; A M Otto; L Jimenez de Asua
Journal: J Cell Physiol Date: 1984-04 Impact factor: 6.384

9. Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

Authors: A Kishimoto; Y Takai; T Mori; U Kikkawa; Y Nishizuka
Journal: J Biol Chem Date: 1980-03-25 Impact factor: 5.157

10. Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C.

Authors: W L Farrar; T P Thomas; W B Anderson
Journal: Nature Date: 1985 May 16-22 Impact factor: 49.962

25 in total

1. A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.

Authors: I N Maruyama; S Brenner
Journal: Proc Natl Acad Sci U S A Date: 1991-07-01 Impact factor: 11.205

2. Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor.

Authors: S Ahmed; R Kozma; C Monfries; C Hall; H H Lim; P Smith; L Lim
Journal: Biochem J Date: 1990-12-15 Impact factor: 3.857

3. The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount.

Authors: B André
Journal: Mol Gen Genet Date: 1990-01

4. Purification of PKC-I, an endogenous protein kinase C inhibitor, and types II and III protein kinase C isoenzymes from human neutrophils.

Authors: K J Balazovich; E L McEwen; M L Lutzke; L A Boxer; T White
Journal: Biochem J Date: 1992-06-01 Impact factor: 3.857

10. Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes.

Authors: C Hall; W C Sin; M Teo; G J Michael; P Smith; J M Dong; H H Lim; E Manser; N K Spurr; T A Jones
Journal: Mol Cell Biol Date: 1993-08 Impact factor: 4.272