| Literature DB >> 31079799 |
Weimin Wang1, Janice Rebecca Liu2, Weiping Zou3.
Abstract
The phenotype and functionalities of the major immune cell subsets including myeloid cells, macrophages, dendritic cells, and T cells are altered in the ovarian cancer microenvironment. Immunosuppressive networks including inhibitory B7 family members and regulatory T cell-associated adenosine pathway have been defined in human ovarian cancer. In this review, the authors integrate emerging information on immunosuppressive mechanisms and T cell phenotype and discuss strategies of immunotherapeutic and vaccine regimens. Finally, crucial points regarding design of immuno-oncology clinical trials are reviewed.Entities:
Keywords: Adoptive T-cell transfer; Cancer vaccine; Checkpoint blockade; Immunotherapy; Ovarian cancer
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Year: 2019 PMID： 31079799 PMCID： PMC7017862 DOI： 10.1016/j.soc.2019.02.002
Source DB: PubMed Journal: Surg Oncol Clin N Am ISSN： 1055-3207 Impact factor: 3.495