| Literature DB >> 31079797 |
Morgan L Hennessy1, Praveen K Bommareddy2, Genevieve Boland1, Howard L Kaufman3.
Abstract
Oncolytic viruses are naturally occurring, or genetically engineered viruses that can be administered via intralesional injections or intravenously to induce cell death in tumor cells and activate antitumor immune responses. This review summarizes several oncolytic viruses in preclinical and clinical trials, describes challenges in clinical implementation, and important areas of future investigation.Entities:
Keywords: Cancer; Immunogenic cell death; Immunotherapy; Intratumoral; Oncolytic virus; Treatment
Mesh：
Year: 2019 PMID： 31079797 DOI： 10.1016/j.soc.2019.02.007
Source DB: PubMed Journal: Surg Oncol Clin N Am ISSN： 1055-3207 Impact factor: 3.495