| Literature DB >> 31079692 |
Stefania Paolillo1, Fabio Marsico2, Maria Prastaro3, Francesco Renga3, Luca Esposito3, Fabiana De Martino3, Pierfrancesco Di Napoli3, Immacolata Esposito3, Antonio Ambrosio3, Monica Ianniruberto3, Rosa Mennella3, Roberta Paolillo3, Paola Gargiulo4.
Abstract
A strict bidirectional relationship exists between diabetes mellitus and heart failure. Diabetic cardiomyopathy is a specific cardiac manifestation of patients with diabetes characterized by left ventricular hypertrophy and diastolic dysfunction in the early phase up to overt heart failure with reduced systolic function in the advanced stages. The pathogenesis of this condition is multifactorial and recognizes as main promoting factors the presence of insulin resistance and hyperglycemia. Diabetic cardiomyopathy exerts a negative prognostic impact in affected patients and no target treatments are currently available. More efforts are needed to better define the diagnostic and therapeutic approach in this specific setting.Entities:
Keywords: Diabetes mellitus; Diabetic cardiomyopathy; Diastolic dysfunction; Heart failure; Systolic dysfunction
Mesh：
Year: 2019 PMID： 31079692 DOI： 10.1016/j.hfc.2019.02.003
Source DB: PubMed Journal: Heart Fail Clin ISSN： 1551-7136 Impact factor: 3.179