| Literature DB >> 31077174 |
Michelle E Penney1, Patrick S Parfrey2, Sevtap Savas1,3, Yildiz E Yilmaz4,5,6.
Abstract
.Entities:
Year: 2019 PMID: 31077174 PMCID: PMC6511186 DOI: 10.1186/s12885-019-5672-7
Source DB: PubMed Journal: BMC Cancer ISSN: 1471-2407 Impact factor: 4.430
Fig. 3Kaplan-Meier survival function for the most significant SNPs in the multivariable analysis under the (a) mixture cure model and (b) Cox proportional hazards regression model. n: number of patients in that genotype category; d: number of metastasis in that genotype category. a rs5749032 was the only SNP maintaining genome-wide significance after the multivariable analysis using the mixture cure model. In the rs5749032 GG genotype subgroup, the clear plateau at approximately 80% metastasis-free survival probability indicates the existence of a large proportion of long-term metastasis-free survivors. b In the rs2327990 TT genotype subgroup, all the patients experienced metastasis within approximately the first two years. Therefore, a standard survival analysis method is appropriate