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Literature DB >> 31076731

A map of β-cell differentiation pathways supports cell therapies for diabetes.

Fabian J Theis, Heiko Lickert.

Abstract

Entities: Chemical

Keywords: Diabetes; Stem cells

Mesh：

Year: 2019 PMID： 31076731 DOI： 10.1038/d41586-019-01211-9

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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6 in total

1. Inferring population dynamics from single-cell RNA-sequencing time series data.

Authors: David S Fischer; Anna K Fiedler; Eric M Kernfeld; Ryan M J Genga; Aimée Bastidas-Ponce; Mostafa Bakhti; Heiko Lickert; Jan Hasenauer; Rene Maehr; Fabian J Theis
Journal: Nat Biotechnol Date: 2019-04-01 Impact factor: 54.908

2. Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.

Authors: Geoffrey Schiebinger; Jian Shu; Marcin Tabaka; Brian Cleary; Vidya Subramanian; Aryeh Solomon; Joshua Gould; Siyan Liu; Stacie Lin; Peter Berube; Lia Lee; Jenny Chen; Justin Brumbaugh; Philippe Rigollet; Konrad Hochedlinger; Rudolf Jaenisch; Aviv Regev; Eric S Lander
Journal: Cell Date: 2019-01-31 Impact factor: 41.582

3. Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

Authors: Gopika G Nair; Jennifer S Liu; Holger A Russ; Stella Tran; Michael S Saxton; Richard Chen; Charity Juang; Mei-Lan Li; Vinh Q Nguyen; Simone Giacometti; Sapna Puri; Yuan Xing; Yong Wang; Gregory L Szot; Jose Oberholzer; Anil Bhushan; Matthias Hebrok
Journal: Nat Cell Biol Date: 2019-02-01 Impact factor: 28.824

4. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells.

Authors: Alireza Rezania; Jennifer E Bruin; Payal Arora; Allison Rubin; Irina Batushansky; Ali Asadi; Shannon O'Dwyer; Nina Quiskamp; Majid Mojibian; Tobias Albrecht; Yu Hsuan Carol Yang; James D Johnson; Timothy J Kieffer
Journal: Nat Biotechnol Date: 2014-09-11 Impact factor: 54.908

A map of β-cell differentiation pathways supports cell therapies for diabetes.

1. Inferring population dynamics from single-cell RNA-sequencing time series data.

2. Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.

3. Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

4. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells.

5. Diffusion pseudotime robustly reconstructs lineage branching.

6. Generation of functional human pancreatic β cells in vitro.

Review 1. Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes.

Review 2. Engineering islets from stem cells for advanced therapies of diabetes.

Review 3. Advances of single-cell genomics and epigenomics in human disease: where are we now?

4. Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro.

Review 5. Applications of iPSC-derived beta cells from patients with diabetes.

Review 6. β-Cell Maturation and Identity in Health and Disease.