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Literature DB >> 31073709

A headache with surprising outcome: first case of brucellosis caused by Brucella suis biovar 1 in Germany.

Sabine Zange^1,2, Kim Schneider³, Enrico Georgi⁴, Holger C Scholz^4,5, Markus H Antwerpen⁴, Mathias C Walter⁴, Lothar Zoeller^4,5, Heiner von Buttlar⁴, Johannes P Borde^6,7.

Abstract

In July 2018, brucellosis was diagnosed in a German patient without a travel history to regions endemic for Brucella. Microbiological analysis, including whole-genome sequencing, revealed Brucella suis biovar 1 as the etiologic agent. Core-genome-based multilocus sequence-typing analysis placed the isolate in close proximity to strains originating from Argentina. Notably, despite a strong IgM response, the patient did not develop Brucella-specific IgG antibodies during infection. Here, we describe the clinical course of infection, the extensive epidemiological investigations, and discuss possible routes of transmission.

Entities: Disease Species

Keywords: Autochthonous; Brucella suis biovar 1; Germany; Serology; Whole-genome sequencing

Mesh：

Substances：
Antibodies, Bacterial

Year: 2019 PMID： 31073709 DOI： 10.1007/s15010-019-01312-7

Source DB: PubMed Journal: Infection ISSN： 0300-8126 Impact factor: 3.553

16 in total

1. Brucella suis infection in domestic pigs and wild boar in Croatia.

Authors: Z Cvetnić; S Spicić; J Toncić; D Majnarić; M Benić; D Albert; M Thiébaud; B Garin-Bastuji
Journal: Rev Sci Tech Date: 2009-12 Impact factor: 1.181

2. Multiplex PCR assay for the identification and differentiation of all Brucella species and the vaccine strains Brucella abortus S19 and RB51 and Brucella melitensis Rev1.

Authors: David García-Yoldi; Clara M Marín; María J de Miguel; Pilar M Muñoz; José L Vizmanos; Ignacio López-Goñi
Journal: Clin Chem Date: 2006-04 Impact factor: 8.327

3. Fatal case of brucellosis misdiagnosed in early stages of Brucella suis infection in a 46-year-old patient with Marfan syndrome.

Authors: M Carrington; U Choe; S Ubillos; D Stanek; M Campbell; L Wansbrough; P Lee; G Churchwell; K Rosas; S R Zaki; C Drew; C D Paddock; M Deleon-Carnes; M Guerra; A R Hoffmaster; R V Tiller; B K De
Journal: J Clin Microbiol Date: 2012-04-11 Impact factor: 5.948

A headache with surprising outcome: first case of brucellosis caused by Brucella suis biovar 1 in Germany.

1. Brucella suis infection in domestic pigs and wild boar in Croatia.

2. Multiplex PCR assay for the identification and differentiation of all Brucella species and the vaccine strains Brucella abortus S19 and RB51 and Brucella melitensis Rev1.

3. Fatal case of brucellosis misdiagnosed in early stages of Brucella suis infection in a 46-year-old patient with Marfan syndrome.

4. A rare case of seronegative culture--proven infection with Brucella suis.

5. Genetic relatedness of Brucella suis biovar 2 isolates from hares, wild boars and domestic pigs.

Review 6. Imported brucellosis: A case series and literature review.

7. The first report of Brucella suis biovar 1 isolation in human in Turkey.

8. Brucella isolated in humans and animals in Latin America from 1968 to 2006.

9. Human brucellosis at a pig slaughterhouse.

10. Brucellosis in two hunt club members in South Carolina.

Review 1. The current therapeutical strategies in human brucellosis.

2. MALDI-TOF MS and genomic analysis can make the difference in the clarification of canine brucellosis outbreaks.