Persistent Hyperlactatemia as the Predictor of Poor Outcome in Critically Ill Children: A Single-Center, Prospective, Observational Cohort Study.

Objective  To study incidence of hyperlactatemia and its correlation with outcome in critically ill children. Design  Single-center, prospective cohort study. Setting  Eight-bedded PICU. Method  Serial serum lactate levels were measured in 140 critically ill children at 0, 12, 24, and 48 hours. Results  A total of 45% children had hyperlactatemia. Lactate levels were significantly ( p  = 0.000) higher in nonsurvivors at all intervals. Lactate levels decreased significantly ( p  = 0.000) in survivors while increased in nonsurvivors. Normalized lactate load was found to be an independent predictor of mortality ( p  = 0.023). Conclusion  Persistent hyperlactatemia serves as a possible predictor of poor outcome in critically ill children.