Literature DB >> 31072638

Designer Drugs for Designer Receptors: Unlocking the Translational Potential of Chemogenetics.

Ofer Yizhar1, J Simon Wiegert2.   

Abstract

Chemogenetic techniques allow selective manipulation of neurons by activating engineered actuator proteins with otherwise inert effector molecules. A recent study (Magnus et al. Science 2019;364:eaav5282) describes the coevolution of highly potent actuator-effector pairs based on a clinically approved antismoking drug. These tools allow selective excitation or inhibition of neurons in the living brain with high specificity and no detectable side-effects.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  chemogenetics; drug design; gene therapy; neuromodulation

Mesh：

Substances：

Year:  2019        PMID： 31072638      PMCID： PMC6548557          DOI： 10.1016/j.tips.2019.04.010

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  10 in total

1.  Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.

Authors:  Juan L Gomez; Jordi Bonaventura; Wojciech Lesniak; William B Mathews; Polina Sysa-Shah; Lionel A Rodriguez; Randall J Ellis; Christopher T Richie; Brandon K Harvey; Robert F Dannals; Martin G Pomper; Antonello Bonci; Michael Michaelides
Journal:  Science       Date:  2017-08-04       Impact factor: 47.728

2.  Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.

Authors:  Blaine N Armbruster; Xiang Li; Mark H Pausch; Stefan Herlitze; Bryan L Roth
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-02       Impact factor: 11.205

3.  Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions.

Authors:  Tara Keck; Taro Toyoizumi; Lu Chen; Brent Doiron; Daniel E Feldman; Kevin Fox; Wulfram Gerstner; Philip G Haydon; Mark Hübener; Hey-Kyoung Lee; John E Lisman; Tobias Rose; Frank Sengpiel; David Stellwagen; Michael P Stryker; Gina G Turrigiano; Mark C van Rossum
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2017-03-05       Impact factor: 6.237

Review 4.  Chemogenetic tools to interrogate brain functions.

Authors:  Scott M Sternson; Bryan L Roth
Journal:  Annu Rev Neurosci       Date:  2014-06-16       Impact factor: 12.449

Review 5.  Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition.

Authors:  Nicolas Doyon; Laurent Vinay; Steven A Prescott; Yves De Koninck
Journal:  Neuron       Date:  2016-03-16       Impact factor: 17.173

6.  Ultrapotent chemogenetics for research and potential clinical applications.

Authors:  Christopher J Magnus; Peter H Lee; Jordi Bonaventura; Roland Zemla; Juan L Gomez; Melissa H Ramirez; Xing Hu; Adriana Galvan; Jayeeta Basu; Michael Michaelides; Scott M Sternson
Journal:  Science       Date:  2019-03-14       Impact factor: 47.728

7.  Chemical and genetic engineering of selective ion channel-ligand interactions.

Authors:  Christopher J Magnus; Peter H Lee; Deniz Atasoy; Helen H Su; Loren L Looger; Scott M Sternson
Journal:  Science       Date:  2011-09-02       Impact factor: 47.728

8.  Rapid formation of clozapine in guinea-pigs and man following clozapine-N-oxide administration.

Authors:  M W Jann; Y W Lam; W H Chang
Journal:  Arch Int Pharmacodyn Ther       Date:  1994 Sep-Oct

9.  The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.

Authors:  Xin Chen; Hyunah Choo; Xi-Ping Huang; Xiaobao Yang; Orrin Stone; Bryan L Roth; Jian Jin
Journal:  ACS Chem Neurosci       Date:  2015-01-27       Impact factor: 4.418

10.  High-efficiency optogenetic silencing with soma-targeted anion-conducting channelrhodopsins.

Authors:  Mathias Mahn; Lihi Gibor; Pritish Patil; Katayun Cohen-Kashi Malina; Shir Oring; Yoav Printz; Rivka Levy; Ilan Lampl; Ofer Yizhar
Journal:  Nat Commun       Date:  2018-10-08       Impact factor: 14.919
  10 in total

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