| Literature DB >> 3107205 |
C Montesissa, G Pompa, F M di Lauro, L Fadini.
Abstract
Fenclor 64 (a PCB's commercial mixture) was administered twice i.p. to virgin and pregnant New Zealand rabbits at the dose of 100 mg/Kg to evaluate its inducing properties on the following hepatic microsomal MFO activities: p-nitro-anisole-O-demethylase, amino-pyrine-N-demethylase, acetanilide-hydroxylase and aryl-hydrocarbons-hydroxylase. The results indicate that Fenclor 64 evoked a "mixed type" induction in virgin as well as in pregnant rabbits since it increased liver weight, cytochrome P-450 levels, as well as p-nitro-anisole-O-demethylase and acetanilide-hydroxylase. Pregnancy by itself affects only amino-pyrine-N-demethylase levels.Entities:
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Year: 1987 PMID： 3107205 DOI： 10.1007/bf00361326
Source DB: PubMed Journal: Vet Res Commun ISSN： 0165-7380 Impact factor: 2.459