| Literature DB >> 31071540 |
Junki Mine1, Yuko Uchida1, Momoko Nakayama1, Taichiro Tanikawa1, Ryota Tsunekuni1, Kirill Sharshov2, Nobuhiro Takemae1, Ivan Sobolev2, Alexander Shestpalov2, Takehiko Saito3.
Abstract
An H5N6 highly pathogenic avian influenza virus (HPAIV) outbreak occurred in poultry in Japan during January 2018, and H5N6 HPAIVs killed several wild birds in 3 prefectures during Winter 2017-2018. Time-measured phylogenetic analyses demonstrated that the Hemagglutinin (HA) and internal genes of these isolates were genetically similar to clade 2.3.4.4.B H5N8 HPAIVs in Europe during Winter 2016-2017, and Neuraminidase (NA) genes of the poultry and wild bird isolates were gained through distinct reassortments with AIVs that were estimated to have circulated possibly in Siberia during Summer 2017 and Summer 2016, respectively. Lethal infectious dose to chickens was similar between the poultry and wild-bird isolates. H5N6 HPAIVs during Winter 2017-2018 in Japan had higher 50% chicken lethal doses and lower transmission efficiency than the H5Nx HPAIVs that caused previous outbreaks in Japan, thus explaining in part why cases during the 2017-2018 outbreak were sporadic.Entities:
Keywords: Animal RNA virus; H5N6 highly pathogenic avian influenza; Pathogenicity; Phylogeny
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Year: 2019 PMID： 31071540 DOI： 10.1016/j.virol.2019.04.011
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616