Marek Jakalski1, Andrzej Bozek1, G Walter Canonica2. 1. Clinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia in Katowice, Poland. 2. Humanitas University, Milano, Italy.
Abstract
Allergen immunotherapy (AIT) is a very useful therapy for allergic rhinitis. However, some patients do not achieve the expected results. The aim of the study was to investigate the potential factors that could affect the result, either good or poor, from AIT. Methods: A retrospective analysis of 1624 patients with allergic rhinitis who underwent AIT and 1519 matched patients who underwent only symptomatic therapy (without AIT) was performed. Symptoms, medications scores and quality of life related to allergic diseases before and after therapy were recorded. Cluster analysis on all of the patients was performed to find any associations between responsiveness to therapy and the analyzed parameters. Responsiveness to therapy was assessed by the Mailing criteria. Results: A total of 1266 (77.8%) patients from the AIT group met the criterion of 30% or greater improvement, and 1061 (65.2%) of these patients met the threshold of 60% or greater improvement according to the Mailing criteria. Patients who had a frequently better response to AIT were highly represented in the two clusters. There were subjects with a short history of allergic rhinitis and concomitant allergy to grass pollen or house dust mites. Patients with a prolonged duration of allergic rhinitis before therapy and with polysensitization were more frequently worse responders to AIT. Conclusion: Responsiveness to therapy, including that to AIT, is difficult to assess. However, there were associations suggesting that short-term allergic rhinitis and monovalent allergies to grass pollen or mites could correspond to a better response to AIT.
Allergen immunotherapy (AIT) is a very useful therapy for allergic rhinitis. However, some patients do not achieve the expected results. The aim of the study was to investigate the potential factors that could affect the result, either good or poor, from AIT. Methods: A retrospective analysis of 1624 patients with allergic rhinitis who underwent AIT and 1519 matched patients who underwent only symptomatic therapy (without AIT) was performed. Symptoms, medications scores and quality of life related to allergic diseases before and after therapy were recorded. Cluster analysis on all of the patients was performed to find any associations between responsiveness to therapy and the analyzed parameters. Responsiveness to therapy was assessed by the Mailing criteria. Results: A total of 1266 (77.8%) patients from the AIT group met the criterion of 30% or greater improvement, and 1061 (65.2%) of these patients met the threshold of 60% or greater improvement according to the Mailing criteria. Patients who had a frequently better response to AIT were highly represented in the two clusters. There were subjects with a short history of allergic rhinitis and concomitant allergy to grass pollen or house dust mites. Patients with a prolonged duration of allergic rhinitis before therapy and with polysensitization were more frequently worse responders to AIT. Conclusion: Responsiveness to therapy, including that to AIT, is difficult to assess. However, there were associations suggesting that short-term allergic rhinitis and monovalent allergies to grass pollen or mites could correspond to a better response to AIT.
Authors: J Augé; J Vent; I Agache; L Airaksinen; P Campo Mozo; A Chaker; C Cingi; S Durham; W Fokkens; P Gevaert; A Giotakis; P Hellings; M Herknerova; V Hox; L Klimek; C La Melia; J Mullol; N B Muluk; A Muraro; K Naito; O Pfaar; H Riechelmann; C Rondon; M Rudenko; B Samolinski; I Tasca; P Tomazic; K Vogt; M Wagenmann; G Yeryomenko; L Zhang; R Mösges Journal: Allergy Date: 2018-03-27 Impact factor: 13.146
Authors: Marek Jutel; Ioana Agache; Sergio Bonini; A Wesley Burks; Moises Calderon; Walter Canonica; Linda Cox; Pascal Demoly; Antony J Frew; Robyn O'Hehir; Jörg Kleine-Tebbe; Antonella Muraro; Gideon Lack; Désirée Larenas; Michael Levin; Bryan L Martin; Harald Nelson; Ruby Pawankar; Oliver Pfaar; Ronald van Ree; Hugh Sampson; James L Sublett; Kazunari Sugita; George Du Toit; Thomas Werfel; Roy Gerth van Wijk; Luo Zhang; Mübeccel Akdis; Cezmi A Akdis Journal: J Allergy Clin Immunol Date: 2016-02 Impact factor: 10.793
Authors: G W Canonica; C E Baena-Cagnani; J Bousquet; P J Bousquet; R F Lockey; H-J Malling; G Passalacqua; P Potter; E Valovirta Journal: Allergy Date: 2007-03 Impact factor: 13.146
Authors: L M Heinzerling; G J Burbach; G Edenharter; C Bachert; C Bindslev-Jensen; S Bonini; J Bousquet; L Bousquet-Rouanet; P J Bousquet; M Bresciani; A Bruno; P Burney; G W Canonica; U Darsow; P Demoly; S Durham; W J Fokkens; S Giavi; M Gjomarkaj; C Gramiccioni; T Haahtela; M L Kowalski; P Magyar; G Muraközi; M Orosz; N G Papadopoulos; C Röhnelt; G Stingl; A Todo-Bom; E von Mutius; A Wiesner; S Wöhrl; T Zuberbier Journal: Allergy Date: 2009-10 Impact factor: 13.146
Authors: S Dhami; U Nurmatov; S Arasi; T Khan; M Asaria; H Zaman; Arnav Agarwal; G Netuveli; G Roberts; O Pfaar; A Muraro; I J Ansotegui; M Calderon; C Cingi; S Durham; R Gerth van Wijk; S Halken; E Hamelmann; P Hellings; L Jacobsen; E Knol; D Larenas-Linnemann; S Lin; P Maggina; R Mösges; H Oude Elberink; G Pajno; R Panwankar; E Pastorello; M Penagos; C Pitsios; G Rotiroti; F Timmermans; O Tsilochristou; E-M Varga; C Schmidt-Weber; J Wilkinson; A Williams; M Worm; L Zhang; A Sheikh Journal: Allergy Date: 2017-07-14 Impact factor: 13.146
Authors: Marek Jutel; Ioana Agache; Sergio Bonini; A Wesley Burks; Moises Calderon; Walter Canonica; Linda Cox; Pascal Demoly; Antony J Frew; Robin O'Hehir; Jörg Kleine-Tebbe; Antonella Muraro; Gideon Lack; Désirée Larenas; Michael Levin; Harald Nelson; Ruby Pawankar; Oliver Pfaar; Ronald van Ree; Hugh Sampson; Alexandra F Santos; George Du Toit; Thomas Werfel; Roy Gerth van Wijk; Luo Zhang; Cezmi A Akdis Journal: J Allergy Clin Immunol Date: 2015-07-07 Impact factor: 10.793
Authors: Ulugbek Nurmatov; Sangeeta Dhami; Stefania Arasi; Graham Roberts; Oliver Pfaar; Antonella Muraro; Ignacio J Ansotegui; Moises Calderon; Cemal Cingi; Stephen Durham; Roy Gerth van Wijk; Susanne Halken; Eckard Hamelmann; Peter Hellings; Lars Jacobsen; Edward Knol; Desiree Larenas-Linnemann; Sandra Y Lin; Vivian Maggina; Hanneke Oude-Elberink; Giovanni Pajno; Ruby Panwankar; Elideanna Pastorello; Constantinos Pitsios; Giuseppina Rotiroti; Frans Timmermans; Olympia Tsilochristou; Eva-Maria Varga; Jamie Wilkinson; Andrew Williams; Margitta Worm; Luo Zhang; Aziz Sheikh Journal: Clin Transl Allergy Date: 2017-08-08 Impact factor: 5.871
Authors: Cristoforo Incorvaia; Erminia Ridolo; Marina Mauro; Francesco Pucciarini; Enrico Heffler; Giorgio Walter Canonica Journal: Front Allergy Date: 2022-02-16