Literature DB >> 3107096

Plausible mechanism of inactivation of plasma alpha 1-proteinase inhibitor by acrolein.

J C Gan, G A Ansari.   

Abstract

Evidence is presented to show that inactivation of alpha 1-proteinase inhibitor caused by acrolein depends upon the modification of lysine and histidine residues. Approximately 90% activity was lost when twenty three lysine and eight histidine residues were modified.

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Year:  1987        PMID： 3107096

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  3 in total

1.  Protein-bound acrolein: potential markers for oxidative stress.

Authors:  K Uchida; M Kanematsu; K Sakai; T Matsuda; N Hattori; Y Mizuno; D Suzuki; T Miyata; N Noguchi; E Niki; T Osawa
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

2.  Synergistic inactivation of plasma alpha 1-proteinase inhibitor by aldehydes of cigarette smoke with styrene oxide and 1,2-dichloroethane.

Authors:  G A Ansari; J C Gan; B K Barton
Journal:  Arch Environ Contam Toxicol       Date:  1988-07       Impact factor: 2.804

3.  In vitro inactivation of plasma alpha 1-proteinase inhibitor by epoxides and 1,2-dihaloethanes.

Authors:  G A Ansari; J C Gan; B K Barton
Journal:  Arch Environ Contam Toxicol       Date:  1988-07       Impact factor: 2.804
  3 in total

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