| Literature DB >> 31070352 |
Zhilan Chai1,2, Danni Ran1,2, Linwei Lu3, Changyou Zhan1,2,4, Huitong Ruan1,2, Xuefeng Hu1,2, Cao Xie1,2, Kuan Jiang1,2, Jinyang Li1,2, Jianfen Zhou1,2, Jing Wang1,2, Yanyu Zhang1,2, Ronnie H Fang5, Liangfang Zhang5, Weiyue Lu1,2,6.
Abstract
The safe and efficient delivery of chemotherapeutic agents remains critical to anticancer therapy. Herein, we report on a targeted drug delivery system based upon a modified cell membrane coating technique and drug nanocrystals (NCs). Specifically, red blood cell (RBC) membrane was modified with targeting peptides through a facile insertion method involving avidin-biotin interactions. The RBC membrane-coated drug NCs (RBC-NCs) exhibited high drug loading, long-term stability, excellent biocompatibility, and prolonged retention time, all of which make them suitable for effective drug delivery. When modified with the tumor-targeting peptide c(RGDyK), the resulting RGD-RBC-NCs showed superior tumor accumulation and therapeutic efficacy both in mice bearing a subcutaneous tumor as well as orthotropic glioma. RBC-NC therapeutics can be readily generalized to the delivery of various drugs and for the treatment of a wide range of cancers.Entities:
Keywords: biomimetic nanocarrier; drug delivery; drug nanocrystal; glioma; tumor-targeting
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Year: 2019 PMID： 31070352 DOI： 10.1021/acsnano.9b00661
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881