Literature DB >> 3107029

The effect of kappa-opioid agonist U-50, 488H on wet-dog shaking behavior induced by hippocampal stimulation in rats.

M Ohno, T Yamamoto, H Araki, S Ueki.   

Abstract

The effect of a selective kappa-opioid agonist, U-50, 488H, on wet-dog shaking (WDS) induced by hippocampal stimulation was investigated and compared with that produced by morphine. U-50, 488H, as well as morphine, inhibited the appearance of WDS in a dose-dependent manner. U-50, 488H was approximately three times more potent than morphine in this effect. Neither drug showed any effect on hippocampal afterdischarge. The inhibition of WDS produced by U-50, 488H was blocked significantly by a kappa-opioid antagonist, MR-2266, but not by naloxone. On the other hand, the inhibitory effect of morphine was completely antagonized by both MR-2266 and naloxone. The present results strongly suggest that not only mu-but also kappa-opioid receptors are involved in the appearance of WDS induced by hippocampal stimulation.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3107029     DOI： 10.1007/bf00217060

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  19 in total

1.  TOLERANCE TO AND PHYSICAL DEPENDENCE ON MORPHINE IN RATS.

Authors:  W R MARTIN; A WIKLER; C G EADES; F T PESCOR
Journal:  Psychopharmacologia       Date:  1963-05-21

2.  The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

Authors:  W R Martin; C G Eades; J A Thompson; R E Huppler; P E Gilbert
Journal:  J Pharmacol Exp Ther       Date:  1976-06       Impact factor: 4.030

3.  "Wet-dog" shake behaviour in the rat: a possible quantitative model of central 5-hydroxytryptamine activity.

Authors:  P Bedard; C J Pycock
Journal:  Neuropharmacology       Date:  1977-10       Impact factor: 5.250

4.  Pharmacological profile of wet-dog shaking induced by electrical stimulation of the fornix in rats.

Authors:  P Slater
Journal:  Pharmacol Res Commun       Date:  1984-03

5.  Studies of wet-dog shake behavior induced by septohippocampal stimulation in the rat.

Authors:  G Le Gal La Salle; E A Cavalheiro; S Feldblum; D Maresova
Journal:  Can J Physiol Pharmacol       Date:  1983-11       Impact factor: 2.273

6.  Evolution of wet dog shakes during kindling in rats: comparison between hippocampal and amygdala kindling.

Authors:  M Lerner-Natoli; G Rondouin; M Baldy-Moulinier
Journal:  Exp Neurol       Date:  1984-01       Impact factor: 5.330

7.  Methionine enkephalin-induced shaking behavior in rats: dissociation from brain serotonin mechanisms.

Authors:  E G Drust; R S Sloviter; J D Conner
Journal:  Neuropharmacology       Date:  1981-05       Impact factor: 5.250

8.  U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

Authors:  P F Vonvoigtlander; R A Lahti; J H Ludens
Journal:  J Pharmacol Exp Ther       Date:  1983-01       Impact factor: 4.030

9.  Behavioral effects of a novel kappa opioid analgesic, U-50488, in rats and rhesus monkeys.

Authors:  A H Tang; R J Collins
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

10.  Studies of carbachol-induced wet-dog shake behavior in rats.

Authors:  L Turski; S J Czuczwar; W Turski; Z Kleinrok
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530
View more
  2 in total

1.  Nalfurafine, the kappa opioid agonist, inhibits icilin-induced wet-dog shakes in rats and antagonizes glutamate release in the dorsal striatum.

Authors:  Jennifer L Werkheiser; Scott M Rawls; Alan Cowan
Journal:  Neuropharmacology       Date:  2006-12-05       Impact factor: 5.250

2.  The effects of morphine treatment and morphine withdrawal on the dynorphin and enkephalin systems in Sprague-Dawley rats.

Authors:  I Nylander; M Vlaskovska; L Terenius
Journal:  Psychopharmacology (Berl)       Date:  1995-04       Impact factor: 4.530
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.