A Bayesian nonlinear mixed-effects location scale model for learning.

We present a Bayesian nonlinear mixed-effects location scale model (NL-MELSM). The NL-MELSM allows for fitting nonlinear functions to the location, or individual means, and the scale, or within-person variance. Specifically, in the context of learning, this model allows the within-person variance to follow a nonlinear trajectory, where it can be determined whether variability reduces during learning. It incorporates a sub-model that can predict nonlinear parameters for both the location and scale. This specification estimates random effects for all nonlinear location and scale parameters that are drawn from a common multivariate distribution. This allows estimation of covariances among the random effects, within and across the location and the scale. These covariances offer new insights into the interplay between individual mean structures and intra-individual variability in nonlinear parameters. We take a fully Bayesian approach, not only for ease of estimation but also for inference because it provides the necessary and consistent information for use in psychological applications, such as model selection and hypothesis testing. To illustrate the model, we use data from 333 individuals, consisting of three age groups, who participated in five learning trials that assessed verbal memory. In an exploratory context, we demonstrate that fitting a nonlinear function to the within-person variance, and allowing for individual variation therein, improves predictive accuracy compared to customary modeling techniques (e.g., assuming constant variance). We conclude by discussing the usefulness, limitations, and future directions of the NL-MELSM.