Literature DB >> 3106801

Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells.

N J Jones, R Cox, J Thacker.   

Abstract

The V79-4 Chinese hamster line was mutagenized and surviving clones screened for X-ray sensitivity using a replica microwell technique. One slightly sensitive clone and 3 clearly sensitive clones were isolated from approximately 5000 screened, and designated irs 1 to irs 4. The 3 more sensitive clones showed different responses to the genotoxic agents mitomycin C (MMC), ethyl methanesulphonate (EMS) and ultraviolet light (UV). irs 1 showed considerable sensitivity to all the agents tested, in the order MMC much greater than EMS greater than UV. irs 2 and irs 3 had similar sensitivities to EMS and to UV (EMS greater than UV) but irs 3 was more sensitive than irs 2 to MMC. None of these mutants is identical in phenotype to previously published mutants.

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Year:  1987        PMID： 3106801     DOI： 10.1016/0167-8817(87)90011-3

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  47 in total

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Authors:  S Lambert; B S Lopez
Journal:  EMBO J       Date:  2000-06-15       Impact factor: 11.598

2.  XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.

Authors:  A J Pierce; R D Johnson; L H Thompson; M Jasin
Journal:  Genes Dev       Date:  1999-10-15       Impact factor: 11.361

3.  Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice.

Authors:  B Deans; C S Griffin; M Maconochie; J Thacker
Journal:  EMBO J       Date:  2000-12-15       Impact factor: 11.598

4.  Complex formation by the human RAD51C and XRCC3 recombination repair proteins.

Authors:  J Y Masson; A Z Stasiak; A Stasiak; F E Benson; S C West
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

5.  Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.

Authors:  Maria Kraakman-van der Zwet; Wilhelmina J I Overkamp; Rebecca E E van Lange; Jeroen Essers; Annemarie van Duijn-Goedhart; Ingrid Wiggers; Srividya Swaminathan; Paul P W van Buul; Abdellatif Errami; Raoul T L Tan; Nicolaas G J Jaspers; Shyam K Sharan; Roland Kanaar; Malgorzata Z Zdzienicka
Journal:  Mol Cell Biol       Date:  2002-01       Impact factor: 4.272

6.  Identification and purification of two distinct complexes containing the five RAD51 paralogs.

Authors:  J Y Masson; M C Tarsounas; A Z Stasiak; A Stasiak; R Shah; M J McIlwraith; F E Benson; S C West
Journal:  Genes Dev       Date:  2001-12-15       Impact factor: 11.361

7.  Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells.

Authors:  I U De Silva; P J McHugh; P H Clingen; J A Hartley
Journal:  Mol Cell Biol       Date:  2000-11       Impact factor: 4.272

8.  Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation.

Authors:  V P Yu; M Koehler; C Steinlein; M Schmid; L A Hanakahi; A J van Gool; S C West; A R Venkitaraman
Journal:  Genes Dev       Date:  2000-06-01       Impact factor: 11.361

9.  Influence of homologous recombinational repair on cell survival and chromosomal aberration induction during the cell cycle in gamma-irradiated CHO cells.

Authors:  Paul F Wilson; John M Hinz; Salustra S Urbin; Peter B Nham; Larry H Thompson
Journal:  DNA Repair (Amst)       Date:  2010-07-01

10.  The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family.

Authors:  R Cartwright; C E Tambini; P J Simpson; J Thacker
Journal:  Nucleic Acids Res       Date:  1998-07-01       Impact factor: 16.971
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