Literature DB >> 31067445

Position Is Destiny: Metabolism and Cell Identity.

Wolfram Goessling1.   

Abstract

CTNNB1, encoding β-catenin, is frequently mutated in hepatocellular carcinoma, the most rapidly growing solid cancer in the US, and activating mutations in this gene are associated with increased expression of glutamine synthetase. A new report by Adebayo Michael et al. (2019) identifies mTOR as a direct target of WNT/β-catenin signaling through increased production of glutamine, which is required for the carcinogenic effects of WNT/β-catenin activity in the liver.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 31067445      PMCID： PMC7066515          DOI： 10.1016/j.cmet.2019.04.008

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations.

Authors:  Adeola O Adebayo Michael; Sungjin Ko; Junyan Tao; Akshata Moghe; Hong Yang; Meng Xu; Jacquelyn O Russell; Tirthadipa Pradhan-Sundd; Silvia Liu; Sucha Singh; Minakshi Poddar; Jayvir S Monga; Pin Liu; Michael Oertel; Sarangarajan Ranganathan; Aatur Singhi; Sandra Rebouissou; Jessica Zucman-Rossi; Silvia Ribback; Diego Calvisi; Natalia Qvartskhava; Boris Görg; Dieter Häussinger; Xin Chen; Satdarshan P Monga
Journal:  Cell Metab       Date:  2019-01-31       Impact factor: 27.287

Review 2.  Hepatocellular Carcinoma.

Authors:  Augusto Villanueva
Journal:  N Engl J Med       Date:  2019-04-11       Impact factor: 91.245

Review 3.  Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology.

Authors:  Jacquelyn O Russell; Satdarshan P Monga
Journal:  Annu Rev Pathol       Date:  2017-11-10       Impact factor: 23.472

4.  Apc tumor suppressor gene is the "zonation-keeper" of mouse liver.

Authors:  Samira Benhamouche; Thomas Decaens; Cécile Godard; Régine Chambrey; David S Rickman; Christophe Moinard; Mireille Vasseur-Cognet; Calvin J Kuo; Axel Kahn; Christine Perret; Sabine Colnot
Journal:  Dev Cell       Date:  2006-06       Impact factor: 12.270

5.  Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial.

Authors:  Andrew X Zhu; Masatoshi Kudo; Eric Assenat; Stéphane Cattan; Yoon-Koo Kang; Ho Yeong Lim; Ronnie T P Poon; Jean-Frederic Blanc; Arndt Vogel; Chao-Long Chen; Etienne Dorval; Markus Peck-Radosavljevic; Armando Santoro; Bruno Daniele; Junji Furuse; Annette Jappe; Kevin Perraud; Oezlem Anak; Dalila B Sellami; Li-Tzong Chen
Journal:  JAMA       Date:  2014-07-02       Impact factor: 56.272

6.  Pivotal role of mTOR signaling in hepatocellular carcinoma.

Authors:  Augusto Villanueva; Derek Y Chiang; Pippa Newell; Judit Peix; Swan Thung; Clara Alsinet; Victoria Tovar; Sasan Roayaie; Beatriz Minguez; Manel Sole; Carlo Battiston; Stijn Van Laarhoven; Maria I Fiel; Analisa Di Feo; Yujin Hoshida; Steven Yea; Sara Toffanin; Alex Ramos; John A Martignetti; Vincenzo Mazzaferro; Jordi Bruix; Samuel Waxman; Myron Schwartz; Matthew Meyerson; Scott L Friedman; Josep M Llovet
Journal:  Gastroenterology       Date:  2008-08-20       Impact factor: 22.682

7.  Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.

Authors:  Shigeki Sekine; Billy Yu-Ang Lan; Melanie Bedolli; Sandy Feng; Matthias Hebrok
Journal:  Hepatology       Date:  2006-04       Impact factor: 17.425

8.  Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.

Authors:  Saireudee Chaturantabut; Arkadi Shwartz; Kimberley J Evason; Andrew G Cox; Kyle Labella; Arnout G Schepers; Song Yang; Mariana Acuña; Yariv Houvras; Liliana Mancio-Silva; Shannon Romano; Daniel A Gorelick; David E Cohen; Leonard I Zon; Sangeeta N Bhatia; Trista E North; Wolfram Goessling
Journal:  Gastroenterology       Date:  2019-01-12       Impact factor: 22.682

9.  Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth.

Authors:  Andrew G Cox; Katie L Hwang; Kristin K Brown; Kimberley Evason; Sebastian Beltz; Allison Tsomides; Keelin O'Connor; Giorgio G Galli; Dean Yimlamai; Sagar Chhangawala; Min Yuan; Evan C Lien; Julia Wucherpfennig; Sahar Nissim; Akihiro Minami; David E Cohen; Fernando D Camargo; John M Asara; Yariv Houvras; Didier Y R Stainier; Wolfram Goessling
Journal:  Nat Cell Biol       Date:  2016-07-18       Impact factor: 28.824

10.  Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial.

Authors:  Edward K Geissler; Andreas A Schnitzbauer; Carl Zülke; Philipp E Lamby; Andrea Proneth; Christophe Duvoux; Patrizia Burra; Karl-Walter Jauch; Markus Rentsch; Tom M Ganten; Jan Schmidt; Utz Settmacher; Michael Heise; Giorgio Rossi; Umberto Cillo; Norman Kneteman; René Adam; Bart van Hoek; Philippe Bachellier; Philippe Wolf; Lionel Rostaing; Wolf O Bechstein; Magnus Rizell; James Powell; Ernest Hidalgo; Jean Gugenheim; Heiner Wolters; Jens Brockmann; André Roy; Ingrid Mutzbauer; Angela Schlitt; Susanne Beckebaum; Christian Graeb; Silvio Nadalin; Umberto Valente; Victor Sánchez Turrión; Neville Jamieson; Tim Scholz; Michele Colledan; Fred Fändrich; Thomas Becker; Gunnar Söderdahl; Olivier Chazouillères; Heikki Mäkisalo; Georges-Philippe Pageaux; Rudolf Steininger; Thomas Soliman; Koert P de Jong; Jacques Pirenne; Raimund Margreiter; Johann Pratschke; Antonio D Pinna; Johann Hauss; Stefan Schreiber; Simone Strasser; Jürgen Klempnauer; Roberto I Troisi; Sherrie Bhoori; Jan Lerut; Itxarone Bilbao; Christian G Klein; Alfred Königsrainer; Darius F Mirza; Gerd Otto; Vincenzo Mazzaferro; Peter Neuhaus; Hans J Schlitt
Journal:  Transplantation       Date:  2016-01       Impact factor: 4.939
  10 in total

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