Jiao Wang1, Albert M Li2, Hugh S Hung San Lam2, Gabriel M Leung1, C Mary Schooling1,3. 1. School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. 2. Department of Pediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. 3. CUNY School of Public Health and Health Policy, City University of New York, New York, New York, USA.
Abstract
OBJECTIVE: This study used two complementary designs, an observational and a Mendelian randomization (MR) study, to assess whether sleep duration causes adiposity in children and adults. METHODS: In Hong Kong's "Children of 1997" birth cohort, the adjusted cross-sectional associations of sleep duration with BMI z score and obesity and overweight were assessed at ~11 years of age. Generalized estimating equations were also used to examine longitudinal associations of sleep duration at ~11 years with annual BMI z score and obesity and overweight at about 11 to 16 years of age. Using MR, this study assessed the association of genetically predicted sleep duration, based on 54 single-nucleotide polymorphisms, applied to genetic studies of adiposity in children (n = 35,668), men (n = 152,893), and women (n = 171,977). RESULTS: Longer sleep was cross-sectionally associated with lower BMI z score at ~11 years of age (-0.13 per category, 95% CI: -0.22 to -0.04) and at about 11 to 16 years of age longitudinally in girls (-0.39, 95% CI: -0.66 to -0.13). Using MR, sleep duration was inversely associated with BMI in children (-0.29 SD per hour, 95% CI: -0.54 to -0.04), but was not clearly associated with BMI in adults, particularly for women. CONCLUSIONS: A small beneficial effect of sleep on BMI in children cannot be ruled out.
OBJECTIVE: This study used two complementary designs, an observational and a Mendelian randomization (MR) study, to assess whether sleep duration causes adiposity in children and adults. METHODS: In Hong Kong's "Children of 1997" birth cohort, the adjusted cross-sectional associations of sleep duration with BMI z score and obesity and overweight were assessed at ~11 years of age. Generalized estimating equations were also used to examine longitudinal associations of sleep duration at ~11 years with annual BMI z score and obesity and overweight at about 11 to 16 years of age. Using MR, this study assessed the association of genetically predicted sleep duration, based on 54 single-nucleotide polymorphisms, applied to genetic studies of adiposity in children (n = 35,668), men (n = 152,893), and women (n = 171,977). RESULTS: Longer sleep was cross-sectionally associated with lower BMI z score at ~11 years of age (-0.13 per category, 95% CI: -0.22 to -0.04) and at about 11 to 16 years of age longitudinally in girls (-0.39, 95% CI: -0.66 to -0.13). Using MR, sleep duration was inversely associated with BMI in children (-0.29 SD per hour, 95% CI: -0.54 to -0.04), but was not clearly associated with BMI in adults, particularly for women. CONCLUSIONS: A small beneficial effect of sleep on BMI in children cannot be ruled out.
Authors: Chiara Lasconi; Matthew C Pahl; James A Pippin; Chun Su; Matthew E Johnson; Alessandra Chesi; Keith Boehm; Elisabetta Manduchi; Kristy Ou; Maria L Golson; Andrew D Wells; Klaus H Kaestner; Struan F A Grant Journal: Sleep Date: 2022-08-11 Impact factor: 6.313
Authors: Jiao Wang; Man Ki Kwok; Shiu Lun Au Yeung; Jie Zhao; Albert Martin Li; Hugh Simon Lam; Gabriel Matthew Leung; Catherine Mary Schooling Journal: Sci Rep Date: 2020-02-21 Impact factor: 4.379
Authors: Bryony L Hayes; Timothy Robinson; Siddhartha Kar; Katherine S Ruth; Konstantinos K Tsilidis; Timothy Frayling; Anna Murray; Richard M Martin; Deborah A Lawlor; Rebecca C Richmond Journal: PLoS Genet Date: 2022-01-21 Impact factor: 5.917