Literature DB >> 3106695

Enhancement of carcinogenesis by the natural anticarcinogen indole-3-carbinol.

G S Bailey, J D Hendricks, D W Shelton, J E Nixon, N E Pawlowski.   

Abstract

Indole-3-carbinol (I3C), a natural constituent of cruciferous vegetables, is an inhibitor in several experimental animal models of carcinogenesis by polynuclear aromatic hydrocarbons or aflatoxin B1 (AFB1) when administered prior to or during carcinogen exposure. For assessment of the postinitiation effects of I3C, rainbow trout were exposed to dietary I3C in two different protocols--before and during AFB1 exposure or after AFB1 exposure only. Preinitiation exposure to I3C reduced AFB1-initiated hepatocellular carcinomas in trout as previously reported, but post-initiation I3C exposure strongly enhanced the tumor incidence above the positive AFB1 control. These results reveal the need for additional research to elucidate the overall effect of I3C on chemical carcinogenesis.

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Year:  1987        PMID： 3106695

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  13 in total

1.  Nature's chemicals and synthetic chemicals: comparative toxicology.

Authors:  B N Ames; M Profet; L S Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

Review 2.  Dietary carcinogens, environmental pollution, and cancer: some misconceptions.

Authors:  B N Ames; L S Gold
Journal:  Med Oncol Tumor Pharmacother       Date:  1990

3.  Allelochemical induction of cytochrome P450 monooxygenases and amelioration of xenobiotic toxicity in Helicoverpa zea.

Authors:  Ren Sen Zeng; Zhimou Wen; Guodong Niu; Mary A Schuler; May R Berenbaum
Journal:  J Chem Ecol       Date:  2007-03       Impact factor: 2.626

Review 4.  Mode of action-based risk assessment of genotoxic carcinogens.

Authors:  Andrea Hartwig; Michael Arand; Bernd Epe; Sabine Guth; Gunnar Jahnke; Alfonso Lampen; Hans-Jörg Martus; Bernhard Monien; Ivonne M C M Rietjens; Simone Schmitz-Spanke; Gerlinde Schriever-Schwemmer; Pablo Steinberg; Gerhard Eisenbrand
Journal:  Arch Toxicol       Date:  2020-06-15       Impact factor: 5.153

5.  Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study.

Authors:  George S Bailey; Ashok P Reddy; Clifford B Pereira; Ulrich Harttig; William Baird; Jan M Spitsbergen; Jerry D Hendricks; Gayle A Orner; David E Williams; James A Swenberg
Journal:  Chem Res Toxicol       Date:  2009-07       Impact factor: 3.739

Review 6.  Vegetables, fruit, and cancer. II. Mechanisms.

Authors:  K A Steinmetz; J D Potter
Journal:  Cancer Causes Control       Date:  1991-11       Impact factor: 2.506

7.  Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors:  L F Bjeldanes; J Y Kim; K R Grose; J C Bartholomew; C A Bradfield
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

Review 8.  Fish models for environmental carcinogenesis: the rainbow trout.

Authors:  G S Bailey; D E Williams; J D Hendricks
Journal:  Environ Health Perspect       Date:  1996-03       Impact factor: 9.031

Review 9.  Perspectives in cancer chemoprevention.

Authors:  G D Stoner; M A Morse; G J Kelloff
Journal:  Environ Health Perspect       Date:  1997-06       Impact factor: 9.031

10.  Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.

Authors:  E Ann Hudson; Lynne M Howells; Barbara Gallacher-Horley; Louise H Fox; Andreas Gescher; Margaret M Manson
Journal:  BMC Cancer       Date:  2003-01-14       Impact factor: 4.430
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