Canan Yildiz1, Mustafa Altay2, Sedat Yildiz3, Yavuz Çağir4, Tolga Akkan5, Yasemin Aydoğan Ünsal6, Esin Beyan6. 1. Didim State Hospital , Aydin , Turkey. 2. Department of Endocrinology and Metabolism , Sağlik Bilimleri Üniversitesi (University of Health Sciences) Keçiören SUAM, Ankara , Turkey. 3. Söke Fehime Faik Kocagöz State Hospital , Aydin , Turkey. 4. Halil Şivgın Çubuk State Hospital , Ankara , Turkey. 5. Çaldiran District State Hospital , Van , Turkey. 6. Department of Internal Medicine , Sağlik Bilimleri Üniversitesi (University of Health Sciences) Keçiören SUAM, Ankara , Turkey.
Abstract
OBJECTIVE: The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers with pulse wave analysis (PWA). SUBJECTS AND METHODS: A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arterial stiffness measurements of the participants in the study were performed with the Mobil-O-Graph PWA device (I.E.M. GmBH, Stolberg, Germany), which makes cuff based oscillometric measurement from the brachial artery. RESULTS: Systolic blood pressure, pulse rate, central systolic blood pressure, cardiac output, heart rate-corrected augmentation index (Aix@75) and pulse wave velocity (PWV) measurements were significantly higher in the hyperthyroid group than in the control group. The heart rate and PWV in the subclinical hyperthyroid group were significantly higher than the control group. In the euthyroid group, systolic blood pressure, central systolic blood pressure, cardiac output, cardiac index and PWV were found significantly higher than the control group. There was also a negative correlation between Aix@75 and thyroid-stimulating hormone (TSH), and a positive correlation between Aix@75 and free thyroid hormones. CONCLUSION: In our study, we observed that the arterial stiffness was adversely affected by an overt or subclinical increase in thyroid hormones and this correlated with thyroid hormone levels. We recommend that PWV measurement, which is a simple method for detecting CVD risk, can be used in these patients.
OBJECTIVE: The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers with pulse wave analysis (PWA). SUBJECTS AND METHODS: A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arterial stiffness measurements of the participants in the study were performed with the Mobil-O-Graph PWA device (I.E.M. GmBH, Stolberg, Germany), which makes cuff based oscillometric measurement from the brachial artery. RESULTS: Systolic blood pressure, pulse rate, central systolic blood pressure, cardiac output, heart rate-corrected augmentation index (Aix@75) and pulse wave velocity (PWV) measurements were significantly higher in the hyperthyroid group than in the control group. The heart rate and PWV in the subclinical hyperthyroid group were significantly higher than the control group. In the euthyroid group, systolic blood pressure, central systolic blood pressure, cardiac output, cardiac index and PWV were found significantly higher than the control group. There was also a negative correlation between Aix@75 and thyroid-stimulating hormone (TSH), and a positive correlation between Aix@75 and free thyroid hormones. CONCLUSION: In our study, we observed that the arterial stiffness was adversely affected by an overt or subclinical increase in thyroid hormones and this correlated with thyroid hormone levels. We recommend that PWV measurement, which is a simple method for detecting CVD risk, can be used in these patients.
Authors: Andrea Grillo; Vincenzo Barbato; Roberta Maria Antonello; Marco Fabio Cola; Gianfranco Parati; Paolo Salvi; Bruno Fabris; Stella Bernardi Journal: J Clin Med Date: 2022-06-01 Impact factor: 4.964
Authors: Wismandari Wisnu; Idrus Alwi; Nafrialdi Nafrialdi; Kuntjoro Harimurti; Tjokorda Gede D Pemayun; Sri Widia A Jusman; Dewi Irawati S Santoso; Alida R Harahap; Suhendro Suwarto; Imam Subekti Journal: Front Endocrinol (Lausanne) Date: 2021-12-20 Impact factor: 5.555
Authors: Stella Bernardi; Andrea Grillo; Roberta Maria Antonello; Marco Fabio Cola; Chiara Dobrinja; Bruno Fabris; Fabiola Giudici Journal: J Endocr Soc Date: 2022-02-06