Literature DB >> 3106650

The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation.

G Calothy, D Laugier, F R Cross, R Jove, T Hanafusa, H Hanafusa.   

Abstract

Previous studies showed that the amino-terminal domain of Rous sarcoma virus p60v-src involved in myristylation and membrane association of the protein is required for morphological transformation and anchorage independence. Analysis of src delection mutants revealed that the amino-terminal one-third of p60v-src, including the membrane-binding domain, is not essential for induction of cell proliferation. These results demonstrated that, in contrast to the cellular target(s) involved in morphological transformation and anchorage independence, the target(s) involved in mitogenic activity is accessible to nonmyristylated src proteins.

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Year:  1987        PMID： 3106650      PMCID： PMC254154     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

1.  Dissociation of transformation parameters using temperature-conditional mutants of Rous sarcoma virus.

Authors:  M J Weber; R R Friis
Journal:  Cell       Date:  1979-01       Impact factor: 41.582

2.  A transformation defective mutant of Rous sarcoma virus inducing chick embryo neuroretinal cell proliferation.

Authors:  G Calothy; F Poirier; G Dambrine; B Pessac
Journal:  Virology       Date:  1978-08       Impact factor: 3.616

3.  Biochemical properties of p60v-src mutants that induce different cell transformation parameters.

Authors:  R Jove; E A Garber; H Iba; H Hanafusa
Journal:  J Virol       Date:  1986-12       Impact factor: 5.103

4.  Transformation of chick embryo neuroretinal cells by Rous sarcoma virus in vitro: induction of cell proliferation.

Authors:  B Pessac; G Calothy
Journal:  Science       Date:  1974-08       Impact factor: 47.728

5.  Biological properties of "partial" transformation mutants of Rous sarcoma virus and characterization of their pp60src kinase.

Authors:  D D Anderson; R P Beckmann; E H Harms; K Nakamura; M J Weber
Journal:  J Virol       Date:  1981-01       Impact factor: 5.103

6.  Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus.

Authors:  B M Sefton; T Hunter; K Beemon; W Eckhart
Journal:  Cell       Date:  1980-07       Impact factor: 41.582

7.  Expression of viral oncogenes in differentiating chick embryo neuroretinal cells infected with avian tumor viruses.

Authors:  G Calothy; F Poirier; G Dambrine; P Mignatti; P Combes; B Pessac
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1980

8.  Stimulation of growth rate of chondrocytes by Rous sarcoma virus is not coordinated with other expressions of the src gene phenotype.

Authors:  A Tanaka; C Parker; A Kaji
Journal:  J Virol       Date:  1980-08       Impact factor: 5.103

9.  Small deletion in src of Rous sarcoma virus modifying transformation phenotypes: identification of 207-nucleotide deletion and its smaller product with protein kinase activity.

Authors:  N Kitamura; M Yoshida
Journal:  J Virol       Date:  1983-06       Impact factor: 5.103

10.  Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src).

Authors:  A D Levinson; S A Courtneidge; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205
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  22 in total

1.  Transcription of a quail gene expressed in embryonic retinal cells is shut off sharply at hatching.

Authors:  M Guermah; P Crisanti; D Laugier; P Dezelee; L Bidou; B Pessac; G Calothy
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

2.  Functional role of GTPase-activating protein in cell transformation by pp60v-src.

Authors:  J E DeClue; W C Vass; M R Johnson; D W Stacey; D R Lowy
Journal:  Mol Cell Biol       Date:  1993-11       Impact factor: 4.272

3.  Down regulation by p60v-src of genes specifically expressed and developmentally regulated in postmitotic quail neuroretina cells.

Authors:  M Guermah; G Gillet; D Michel; D Laugier; G Brun; G Calothy
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

4.  Identification of a phorbol ester-repressible v-src-inducible gene.

Authors:  D L Simmons; D B Levy; Y Yannoni; R L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

5.  Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability.

Authors:  H C Wang; J T Parsons
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

6.  A single point mutation has pleiotropic effects on pp60v-src function.

Authors:  M J Welham; J A Wyke
Journal:  J Virol       Date:  1988-06       Impact factor: 5.103

7.  The truncated form of the Epstein-Barr virus latent-infection membrane protein expressed in virus replication does not transform rodent fibroblasts.

Authors:  D Wang; D Liebowitz; E Kieff
Journal:  J Virol       Date:  1988-07       Impact factor: 5.103

8.  The sites of phosphorylation by protein kinase C and an intact SH2 domain are required for the enhanced response to beta-adrenergic agonists in cells overexpressing c-src.

Authors:  J S Moyers; A H Bouton; S J Parsons
Journal:  Mol Cell Biol       Date:  1993-04       Impact factor: 4.272

9.  Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis.

Authors:  S Bagrodia; S J Taylor; D Shalloway
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

10.  Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line.

Authors:  G Q Daley; R A Van Etten; P K Jackson; A Bernards; D Baltimore
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272
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