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Literature DB >> 31066433

SO₂F₂ mediated transformation of pyrazolones into pyrazolyl fluorosulfates.

Abstract

The construction of a class of novel N-heterocyclic molecules containing both pyrazole and fluorosulfate functionalities was achieved through the reactions of pyrazolones with SO2F2 in good to excellent yields. The fluorosulfate moieties were utilized as versatile building blocks in the Suzuki coupling reaction and SuFEx click chemistry.

Entities: Chemical Disease

Year: 2019 PMID： 31066433 DOI： 10.1039/c9ob00903e

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

3 in total

1. SO₂F₂-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN).

Authors: Yiyong Zhao; Junjie Wei; Shuting Ge; Guofu Zhang; Chengrong Ding
Journal: RSC Adv Date: 2020-05-04 Impact factor: 4.036

2. SO₂F₂ mediated cascade dehydrogenative Morita-Baylis-Hillman reaction of the C(sp³)-H of primary alcohols with the C(sp²)-H of electron-deficient olefins for the assembly of allylic alcohols.

Authors: Ying Jiang; Njud S Alharbi; Bing Sun; Hua-Li Qin
Journal: RSC Adv Date: 2019-09-20 Impact factor: 3.361

3. Fluorosulfate-containing pyrazole heterocycles as selective BuChE inhibitors: structure-activity relationship and biological evaluation for the treatment of Alzheimer's disease.

Authors: Huan-Huan Li; Chengyao Wu; Shi-Long Zhang; Jian-Guo Yang; Hua-Li Qin; Wenjian Tang
Journal: J Enzyme Inhib Med Chem Date: 2022-12 Impact factor: 5.756

3 in total

SO2F2 mediated transformation of pyrazolones into pyrazolyl fluorosulfates.

1. SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN).

2. SO2F2 mediated cascade dehydrogenative Morita-Baylis-Hillman reaction of the C(sp3)-H of primary alcohols with the C(sp2)-H of electron-deficient olefins for the assembly of allylic alcohols.

3. Fluorosulfate-containing pyrazole heterocycles as selective BuChE inhibitors: structure-activity relationship and biological evaluation for the treatment of Alzheimer's disease.

SO₂F₂ mediated transformation of pyrazolones into pyrazolyl fluorosulfates.

1. SO₂F₂-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN).

2. SO₂F₂ mediated cascade dehydrogenative Morita-Baylis-Hillman reaction of the C(sp³)-H of primary alcohols with the C(sp²)-H of electron-deficient olefins for the assembly of allylic alcohols.