Literature DB >> 31065935

High-Voltage-Activated Calcium Channel in the Afferent Pain Pathway: An Important Target of Pain Therapies.

Qi Li1, Jian Lu1,2, Xiaoxin Zhou1, Xuemei Chen1, Diansan Su1, Xiyao Gu3, Weifeng Yu4.   

Abstract

High-voltage-activated (HVA) Ca2+ channels are widely expressed in the nervous system. They play an important role in pain conduction by participating in various physiological processes such as synaptic transmission, changes in synaptic plasticity, and neuronal excitability. Available evidence suggests that the HVA channel is an important therapeutic target for pain management. In this review, we summarize the changes in different subtypes of HVA channel during pain and present the currently available evidence from the clinical application of HVA channel blockers. We also review novel drugs in various phases of development. Moreover, we discuss the future prospects of HVA channel blockers in order to promote "bench-to-bedside" translation.

Entities:  

Keywords:  Dorsal root ganglion; High-voltage-activated calcium channel; Pain

Mesh：

Substances：

Year:  2019        PMID： 31065935      PMCID： PMC6864004          DOI： 10.1007/s12264-019-00378-5

Source DB:  PubMed          Journal:  Neurosci Bull        ISSN： 1995-8218            Impact factor:   5.203


  98 in total

1.  L-type voltage-gated Ca2+ channels: a single molecular switch for long-term potentiation/long-term depression-like plasticity and activity-dependent metaplasticity in humans.

Authors:  Katharina Wankerl; David Weise; Reinhard Gentner; Jost-Julian Rumpf; Joseph Classen
Journal:  J Neurosci       Date:  2010-05-05       Impact factor: 6.167

2.  Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II.

Authors:  Meagan A Jenkins; Carl J Christel; Yuxia Jiao; Sunday Abiria; Kristin Y Kim; Yuriy M Usachev; Gerald J Obermair; Roger J Colbran; Amy Lee
Journal:  J Neurosci       Date:  2010-04-14       Impact factor: 6.167

Review 3.  Gabapentin for chronic neuropathic pain in adults.

Authors:  Philip J Wiffen; Sheena Derry; Rae F Bell; Andrew Sc Rice; Thomas Rudolf Tölle; Tudor Phillips; R Andrew Moore
Journal:  Cochrane Database Syst Rev       Date:  2017-06-09

Review 4.  Etiology and Pharmacology of Neuropathic Pain.

Authors:  Sascha R A Alles; Peter A Smith
Journal:  Pharmacol Rev       Date:  2018-04       Impact factor: 25.468

5.  Blockade of spinal N- and P-type, but not L-type, calcium channels inhibits the excitability of rat dorsal horn neurones produced by subcutaneous formalin inflammation.

Authors:  A Diaz; A H Dickenson
Journal:  Pain       Date:  1997-01       Impact factor: 6.961

Review 6.  The Role of Calcium Channels in Epilepsy.

Authors:  Sanjeev Rajakulendran; Michael G Hanna
Journal:  Cold Spring Harb Perspect Med       Date:  2016-01-04       Impact factor: 6.915

7.  A consensus statement regarding the present suggested titration for prialt (ziconotide).

Authors:  Robert Fisher; Sam Hassenbusch; Elliot Krames; Michael Leong; Michael Minehart; Joshua Prager; Peter Staats; Lynn Webster; K Dean Willis
Journal:  Neuromodulation       Date:  2005-07

8.  L type Ca²+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats.

Authors:  Takehiro Kawashiri; Nobuaki Egashira; Kentaro Kurobe; Kuniaki Tsutsumi; Yuji Yamashita; Soichiro Ushio; Takahisa Yano; Ryozo Oishi
Journal:  Mol Pain       Date:  2012-01-31       Impact factor: 3.395

9.  Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.

Authors:  Elena Dragicevic; Christina Poetschke; Johanna Duda; Falk Schlaudraff; Stephan Lammel; Julia Schiemann; Michael Fauler; Andrea Hetzel; Masahiko Watanabe; Rafael Lujan; Robert C Malenka; Joerg Striessnig; Birgit Liss
Journal:  Brain       Date:  2014-06-16       Impact factor: 13.501

10.  Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.

Authors:  Nadine J Ortner; Gabriella Bock; David H F Vandael; Robert Mauersberger; Henning J Draheim; Ronald Gust; Emilio Carbone; Petronel Tuluc; Jörg Striessnig
Journal:  Nat Commun       Date:  2014-06-19       Impact factor: 14.919
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  4 in total

1.  The neuronal potassium current IA is a potential target for pain during chronic inflammation.

Authors:  Michael Biet; Marc-André Dansereau; Philippe Sarret; Robert Dumaine
Journal:  Physiol Rep       Date:  2021-08

Review 2.  Voltage-dependent CaV3.2 and CaV2.2 channels in nociceptive pathways.

Authors:  Lucia Hoppanova; Lubica Lacinova
Journal:  Pflugers Arch       Date:  2022-01-18       Impact factor: 3.657

3.  Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain.

Authors:  Qi Li; Zi-Yu Zhu; Jian Lu; Yu-Chieh Chao; Xiao-Xin Zhou; Ying Huang; Xue-Mei Chen; Dian-San Su; Wei-Feng Yu; Xi-Yao Gu
Journal:  Acta Neuropathol Commun       Date:  2019-12-23       Impact factor: 7.801

4.  Growth Differentiation Factor-15 Produces Analgesia by Inhibiting Tetrodotoxin-Resistant Nav1.8 Sodium Channel Activity in Rat Primary Sensory Neurons.

Authors:  Wei Lin; Wen-Wen Zhang; Ning Lyu; Hong Cao; Wen-Dong Xu; Yu-Qiu Zhang
Journal:  Neurosci Bull       Date:  2021-06-02       Impact factor: 5.203
  4 in total

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