Literature DB >> 31063745

SIRT1 Regulates Lysosome Function and Exosome Secretion.

Kathleen M McAndrews1, Valerie S LeBleu2, Raghu Kalluri3.   

Abstract

The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) regulates cell metabolism, proliferation, and DNA repair and acts as a tumor suppressor in breast cancer. In this issue of Developmental Cell, Latifkar et al. show that SIRT1 controls lysosomal acidification and its loss enhances the secretion of pro-tumorigenic exosomes for breast cancer invasion.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 31063745     DOI： 10.1016/j.devcel.2019.04.024

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  9 in total

1.  Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion.

Authors:  Andrew M Leidal; Jayanta Debnath
Journal:  FASEB Bioadv       Date:  2021-03-02

2.  Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1α mitochondrial metabolic pathway.

Authors:  Zhen Zhou; Dan Ma; Peifan Li; Ping Wang; Ping Liu; Danna Wei; Jun Wang; Zhong Qin; Qin Fang; Jishi Wang
Journal:  Aging (Albany NY)       Date:  2020-06-22       Impact factor: 5.682

3.  Down Regulation of SIRT2 Reduced ASS Induced NSCLC Apoptosis Through the Release of Autophagy Components via Exosomes.

Authors:  Lei Wang; Pei Xu; Xiao Xie; Fengqing Hu; Lianyong Jiang; Rui Hu; Fangbao Ding; Haibo Xiao; Huijun Zhang
Journal:  Front Cell Dev Biol       Date:  2020-12-03

4.  Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model.

Authors:  Chunni Zhu; Tina Bilousova; Samantha Focht; Michael Jun; Chris Jean Elias; Mikhail Melnik; Sujyoti Chandra; Jesus Campagna; Whitaker Cohn; Asa Hatami; Patricia Spilman; Karen Hoppens Gylys; Varghese John
Journal:  Mol Brain       Date:  2021-04-19       Impact factor: 4.041

5.  NBPF4 mitigates progression in colorectal cancer through the regulation of EZH2-associated ETFA.

Authors:  Wankun Chen; Zhou Di; Zhaoyuan Chen; Ke Nan; Jiahui Gu; Feng Ge; Jinlong Liu; Hao Zhang; Changhong Miao
Journal:  J Cell Mol Med       Date:  2021-08-18       Impact factor: 5.310

6.  Application of two-dimensional difference gel electrophoresis to identify protein changes between center, margin, and adjacent non-tumor tissues obtained from non-small-cell lung cancer with adenocarcinoma or squamous cell carcinoma subtype.

Authors:  Andrzej Ciereszko; Mariola A Dietrich; Mariola Słowińska; Joanna Nynca; Michał Ciborowski; Monika M Kaczmarek; Kamil Myszczyński; Joanna Kiśluk; Anna Majewska; Anna Michalska-Falkowska; Natalia Kodzik; Joanna Reszeć; Ewa Sierko; Jacek Nikliński
Journal:  PLoS One       Date:  2022-05-05       Impact factor: 3.752

Review 7.  Extralysosomal cathepsin B in central nervous system: Mechanisms and therapeutic implications.

Authors:  Junjun Ni; Fei Lan; Yan Xu; Hiroshi Nakanishi; Xue Li
Journal:  Brain Pathol       Date:  2022-04-12       Impact factor: 7.611

8.  Sirt1 during childhood is associated with microvascular function later in life.

Authors:  Paula Rodriguez-Miguelez; Jacob Looney; Jeffrey Thomas; Gregory Harshfield; Jennifer S Pollock; Ryan A Harris
Journal:  Am J Physiol Heart Circ Physiol       Date:  2020-04-24       Impact factor: 4.733

Review 9.  The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling.

Authors:  Zhuo Wang; Wendong Guo; Fei Yi; Tingting Zhou; Xiaoman Li; Yanling Feng; Qiqiang Guo; Hongde Xu; Xiaoyu Song; Liu Cao
Journal:  Int J Biol Sci       Date:  2021-01-01       Impact factor: 6.580
  9 in total

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