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Literature DB >> 31063551

Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-α.

Baojian Xue^1,2, Yang Yu³, Shun-Guang Wei^2,3, Terry G Beltz¹, Fang Guo¹, Robert B Felder^2,3, Alan Kim Johnson^1,2,4,5.

Abstract

BACKGROUND: Post-traumatic stress disorder (PTSD) is characterized by a disordered stress response and associated with increased cardiovascular disease risk. The present study investigated whether angiotensin (Ang) II-elicited hypertensive response is sensitized in a model of PTSD and whether inhibition of angiotensin-converting enzyme (ACE) or tumor necrosis factor (TNF)-α prior to PTSD blocks this sensitization of Ang II hypertension.
METHODS: The resident-intruder paradigm was used to model PTSD. Each intruder rat (male Sprague-Dawley) was given normal drinking water or was pretreated with either an ACE inhibitor (captopril) or a TNF-α inhibitor (pentoxifylline) in the drinking water for 2 weeks. Subsequently, they were exposed to a different resident (male Long-Evans) for 2 hours on 3 days with each session separated by 1 day and then received a subcutaneous infusion of Ang II for 2 weeks.
RESULTS: The stressed rats had a significantly enhanced hypertensive response to the Ang II infusion (stressed Δ40.2 ± 3.9 mm Hg vs. unstressed Δ20.5 ± 4.5 mm Hg) and an upregulation of mRNA or protein expression of renin-angiotensin system (RAS) and proinflammatory cytokine (PIC) components and of a microglial marker in the lamina terminalis and hypothalamic paraventricular nucleus when compared with unstressed control rats. Both the sensitized hypertensive response and enhanced gene and protein expression were blocked by pretreatment with either ACE (Δ21.3 ± 3.9 mm Hg) or TNF-α inhibitor (Δ21.4 ± 2.6 mm Hg).
CONCLUSIONS: The results indicate that upregulation of the brain RAS and PICs produced by severe stress contributes to traumatic-induced sensitization of hypertensive response to Ang II, and disorders such as PTSD may predispose individuals to development of hypertension. © American Journal of Hypertension, Ltd 2019. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Entities: Chemical Disease Gene Mutation Species

Keywords: blood pressure; hypertension; inflammation; rennin–angiotensin system; traumatic stress

Mesh：

Substances：

Year: 2019 PMID： 31063551 PMCID： PMC6694013 DOI： 10.1093/ajh/hpz075

Source DB: PubMed Journal: Am J Hypertens ISSN： 0895-7061 Impact factor: 2.689

57 in total

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Authors: Roland von Känel; Urs Hepp; Bernd Kraemer; Rafael Traber; Marius Keel; Ladislav Mica; Ulrich Schnyder
Journal: J Psychiatr Res Date: 2006-08-09 Impact factor: 4.791

7. Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action.

Authors: Paresh Dandona; Vikramjeet Kumar; Ahmad Aljada; Husam Ghanim; Tufail Syed; Debborah Hofmayer; Priya Mohanty; Devjit Tripathy; Rajesh Garg
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8. Captopril and enalapril improve cognition and depressed mood in hypertensive patients.

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Journal: J Basic Clin Physiol Pharmacol Date: 2003

9. Chronic administration of an angiotensin II receptor antagonist resets the hypothalamic-pituitary-adrenal (HPA) axis and improves the affect of patients with diabetes mellitus type 2: preliminary results.

Authors: Maria G Pavlatou; George Mastorakos; Ioannis Lekakis; Stavros Liatis; Georgia Vamvakou; Emmanuel Zoumakis; Ioannis Papassotiriou; Andreas D Rabavilas; Nikolaos Katsilambros; George P Chrousos
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Authors: Vasilios Papademetriou; Csaba Farsang; Dag Elmfeldt; Albert Hofman; Hans Lithell; Bertil Olofsson; Ingmar Skoog; Peter Trenkwalder; Alberto Zanchetti
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8 in total

1. Blockade of angiotensin-converting enzyme or tumor necrosis factor-α reverses maternal high-fat diet-induced sensitization of angiotensin II hypertension in male rat offspring.

Authors: Xue-Fang Wang; Jian-Dong Li; Yan-Li Huo; Yu-Ping Zhang; Zhi-Qin Fang; Hai-Ping Wang; Wei Peng; Alan Kim Johnson; Baojian Xue
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2019-11-20 Impact factor: 3.619

2. Voluntary Exercise Eliminates Maternal Gestational Hypertension-Induced Hypertensive Response Sensitization to Postweaning High-Fat Diet in Male Adult Offspring.

Authors: Baojian Xue; Yang Yu; Terry G Beltz; Fang Guo; Shun-Guang Wei; Alan Kim Johnson
Journal: Hypertension Date: 2022-06-22 Impact factor: 9.897

Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-α.

Review 1. Circuits and mechanisms governing hypothalamic responses to stress: a tale of two paradigms.

Review 2. Stressor specificity of central neuroendocrine responses: implications for stress-related disorders.

3. A new test for aggression in rats without aversive stimulation: differential effects of d-amphetamine and cocaine.

Review 4. Chronic mental stress is a cause of essential hypertension: presence of biological markers of stress.

Review 5. Mental "stress" and hypertension. Evidence from animal and experimental studies.

6. Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder.

7. Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action.

8. Captopril and enalapril improve cognition and depressed mood in hypertensive patients.

9. Chronic administration of an angiotensin II receptor antagonist resets the hypothalamic-pituitary-adrenal (HPA) axis and improves the affect of patients with diabetes mellitus type 2: preliminary results.

10. Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension: the Study on Cognition and Prognosis in the Elderly (SCOPE).

1. Blockade of angiotensin-converting enzyme or tumor necrosis factor-α reverses maternal high-fat diet-induced sensitization of angiotensin II hypertension in male rat offspring.

2. Voluntary Exercise Eliminates Maternal Gestational Hypertension-Induced Hypertensive Response Sensitization to Postweaning High-Fat Diet in Male Adult Offspring.

3. Amphetamine-induced sensitization of hypertension and lamina terminalis neuroinflammation.

Review 4. Central nervous system neuroplasticity and the sensitization of hypertension.

Review 5. The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation.

6. Voluntary Exercise Prevents Hypertensive Response Sensitization Induced by Angiotensin II.

7. Predator Scent-Induced Sensitization of Hypertension and Anxiety-like Behaviors.

8. Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice.